6HGA
Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Interleukin-17 receptor C | polymer | 264 | 29792.1 | 1 | UniProt (Q8NAC3) Pfam (PF15037) | Homo sapiens (Human) | IL-17RC,Interleukin-17 receptor homolog,IL17Rhom,Interleukin-17 receptor-like protein,IL-17RL,ZcytoR14 |
| 2 | B (H) | anti-APP-tag Fab heavy-chain | polymer | 222 | 23832.6 | 1 | Mus musculus (House mouse) | 6E10A5 Fab | |
| 3 | C (L) | anti-APP-tag Fab light-chain | polymer | 219 | 24150.8 | 1 | Mus musculus (House mouse) | 6E10A5 Fab | |
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E, F (H, L) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
B: 208 - 467 (UniProt: Q8NAC3)
| PDB | External Database | Details |
|---|---|---|
| Gln 263 | Asn 263 | engineered mutation |
| Arg 307 | Gln 307 | variant |
| Gln 349 | Asn 349 | engineered mutation |
| Gln 372 | Asn 372 | engineered mutation |
| Gln 406 | Asn 406 | engineered mutation |
| Glu 468 | - | expression tag |
| Phe 469 | - | expression tag |
| Arg 470 | - | expression tag |
| His 471 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 77775.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 77996.7 |
