5EW3

Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993

Summary for 5EW3

Entry DOI	10.2210/pdb5ew3/pdb
Descriptor	Vascular endothelial growth factor receptor 2, 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide (3 entities in total)
Functional Keywords	kdr, kinase domain, atp-binding site, vegfr2 inhibitors, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains	2
Total formula weight	73132.24
Authors	Stark, W.,Goepfert, A. (deposition date: 2015-11-20, release date: 2015-12-16, Last modification date: 2024-01-10)
Primary citation	Bold, G.,Schnell, C.,Furet, P.,McSheehy, P.,Bruggen, J.,Mestan, J.,Manley, P.W.,Druckes, P.,Burglin, M.,Durler, U.,Loretan, J.,Reuter, R.,Wartmann, M.,Theuer, A.,Bauer-Probst, B.,Martiny-Baron, G.,Allegrini, P.,Goepfert, A.,Wood, J.,Littlewood-Evans, A. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J.Med.Chem., 59:132-146, 2016 Cited by PubMed: 26629594 DOI: 10.1021/acs.jmedchem.5b01582 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation