5EW3

Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Vascular endothelial growth factor receptor 2	polymer	316	36194.8	2	UniProt (P35968) Pfam (PF07714) In PDB	Homo sapiens (Human)	VEGFR-2,Fetal liver kinase 1,FLK-1,Kinase insert domain receptor,KDR,Protein-tyrosine kinase receptor flk-1
2	A, B	2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide	non-polymer		371.4	2	Chemie (5T2)
3		water	water		18.0	76	Chemie (HOH)

Sequence modifications

A, B: 806 - 1171 (UniProt: P35968)

PDB	External Database	Details
-	Lys 941	deletion
-	Gly 942	deletion
-	Ala 943	deletion
-	Arg 944	deletion
-	Phe 945	deletion
-	Arg 946	deletion
-	Gln 947	deletion
-	Gly 948	deletion
-	Lys 949	deletion
-	Asp 950	deletion
-	Tyr 951	deletion
-	Val 952	deletion
-	Gly 953	deletion
-	Ala 954	deletion
-	Ile 955	deletion
-	Pro 956	deletion
-	Val 957	deletion
-	Asp 958	deletion
-	Leu 959	deletion
-	Lys 960	deletion
-	Arg 961	deletion
-	Arg 962	deletion
-	Leu 963	deletion
-	Asp 964	deletion
-	Ser 965	deletion
-	Ile 966	deletion
-	Thr 967	deletion
-	Ser 968	deletion
-	Ser 969	deletion
-	Gln 970	deletion
-	Ser 971	deletion
-	Ser 972	deletion
-	Ala 973	deletion
-	Ser 974	deletion
-	Ser 975	deletion
-	Gly 976	deletion
-	Phe 977	deletion
-	Val 978	deletion
-	Glu 979	deletion
-	Glu 980	deletion
-	Lys 981	deletion
-	Ser 982	deletion
-	Leu 983	deletion
-	Ser 984	deletion
-	Asp 985	deletion
-	Val 986	deletion
-	Glu 987	deletion
-	Glu 988	deletion
-	Glu 989	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72389.5
Non-Polymers*	Number of molecules	2
	Total formula weight	742.7
All*	Total formula weight	73132.2

*Water molecules are not included.