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6AMH
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BU of 6amh by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Ser bound as E(Aex1)
分子名称: SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
著者Buller, A.R.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AM7
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BU of 6am7 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AMI
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BU of 6ami by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Trp non-covalently bound
分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1
著者Buller, A.R.
登録日2017-08-09
公開日2018-05-16
最終更新日2022-03-23
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AMC
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BU of 6amc by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11
分子名称: SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, Herger, M.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AM8
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BU of 6am8 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9 with Trp bound as E(Aex2)
分子名称: SODIUM ION, TRYPTOPHAN, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
6AM9
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BU of 6am9 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser-bound in a predominantly closed state.
分子名称: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, SODIUM ION, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-08-09
公開日2018-05-16
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
4IHD
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BU of 4ihd by Molmil
Crystal Structure of Uncleaved ThnT T282C, derivatized at the active site with EtHg
分子名称: ETHYL MERCURY ION, ThnT protein
著者Buller, A.R, Schildbach, J.F, Townsend, C.A.
登録日2012-12-18
公開日2014-08-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT.
Biochemistry, 53, 2014
4IHE
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BU of 4ihe by Molmil
Crystal Structure of Uncleaved ThnT T282A
分子名称: ThnT protein
著者Buller, A.R, Schildbach, J.F, Townsend, C.A.
登録日2012-12-18
公開日2014-08-13
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT.
Biochemistry, 53, 2014
5VM5
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BU of 5vm5 by Molmil
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser bound
分子名称: 2-{[(E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}prop-2-enoic acid, SODIUM ION, Tryptophan synthase beta chain 1, ...
著者Buller, A.R, van Roye, P.
登録日2017-04-26
公開日2017-05-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140, 2018
5DW3
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BU of 5dw3 by Molmil
Tryptophan Synthase beta-subunit from Pyrococcus furiosus with product L-tryptophan non-covalently bound in the active site
分子名称: PHOSPHATE ION, SODIUM ION, TRYPTOPHAN, ...
著者Buller, A.R, Arnold, F.H.
登録日2015-09-22
公開日2015-11-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.74 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DVZ
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BU of 5dvz by Molmil
Holo TrpB from Pyrococcus furiosus
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Buller, A.R, Arnold, F.H.
登録日2015-09-21
公開日2016-02-03
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
5DW0
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BU of 5dw0 by Molmil
TrpB from Pyrococcus furiosus with L-serine bound as the external aldimine
分子名称: SODIUM ION, Tryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
著者Buller, A.R, Arnold, F.H.
登録日2015-09-22
公開日2015-11-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
5E0K
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BU of 5e0k by Molmil
X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A
分子名称: PHOSPHATE ION, Tryptophan synthase alpha chain, Tryptophan synthase beta chain 1
著者Buller, A.R, Murciano-Calles, J, Arnold, F.H.
登録日2015-09-29
公開日2015-11-11
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (2.76 Å)
主引用文献Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation.
Proc.Natl.Acad.Sci.USA, 112, 2015
5T6M
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BU of 5t6m by Molmil
Structure of the tryptophan synthase b-subunit from Pyroccus furiosus with b-methyltryptophan non-covalently bound
分子名称: (betaS)-beta-methyl-L-tryptophan, PHOSPHATE ION, SODIUM ION, ...
著者Buller, A.R, van Roye, P, Arnold, F.H.
登録日2016-09-01
公開日2016-12-21
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity.
Biochemistry, 55, 2016
5BV5
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BU of 5bv5 by Molmil
Structure of CYP119 with T213A and C317H mutations
分子名称: 4-PHENYL-1H-IMIDAZOLE, Cytochrome P450 119, PHOSPHATE ION, ...
著者Buller, A.R, Heel, T, McIntosh, J.A, Arnold, F.H.
登録日2015-06-04
公開日2016-02-03
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.
J.Am.Chem.Soc., 137, 2015
5IXJ
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BU of 5ixj by Molmil
Tryptophan Synthase beta-subunit from Pyrococcus furiosus with L-threonine non-covalently bound in the active site
分子名称: SODIUM ION, THREONINE, Tryptophan synthase beta chain 1
著者Buller, A.R, Herger, M, Arnold, F.H.
登録日2016-03-23
公開日2016-08-17
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献Synthesis of beta-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase.
J.Am.Chem.Soc., 138, 2016
8SF6
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BU of 8sf6 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in closed conformation
分子名称: 2-(2-ETHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
著者Buller, A.R, Zmich, A.P, Bingman, C.A.
登録日2023-04-10
公開日2023-12-27
実験手法X-RAY DIFFRACTION (1.702 Å)
主引用文献Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
8SF5
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BU of 8sf5 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in open conformation
分子名称: O-acetylhomoserine/O-acetylserine sulfhydrylase
著者Buller, A.R, Zmich, A.P, Bingman, C.A.
登録日2023-04-10
公開日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
3TM1
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BU of 3tm1 by Molmil
Crystal structure of mature ThnT, a pantetheine hydrolase
分子名称: GLYCEROL, cysteine transferase
著者Schildbach, J.F, Wright, N.T, Buller, A.R.
登録日2011-08-30
公開日2012-07-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
J.Mol.Biol., 422, 2012
3S3U
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BU of 3s3u by Molmil
Crystal Structure of Uncleaved ThnT T282C
分子名称: cysteine transferase
著者Schildbach, J.F, Wright, N.T, Buller, A.R.
登録日2011-05-18
公開日2012-02-01
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TM2
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BU of 3tm2 by Molmil
Crystal structure of mature ThnT with a covalently bound product mimic
分子名称: (2R)-N-(4-chloro-3-oxobutyl)-2,4-dihydroxy-3,3-dimethylbutanamide, cysteine transferase
著者Schildbach, J.F, Wright, N.T, Buller, A.R.
登録日2011-08-30
公開日2012-07-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis.
J.Mol.Biol., 422, 2012
4WG2
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BU of 4wg2 by Molmil
P411BM3-CIS T438S I263F regioselective C-H amination catalyst
分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Hyster, T.K, Farwell, C.C, Buller, A.R, McIntosh, J.A, Arnold, F.H.
登録日2014-09-17
公開日2014-11-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-h amination.
J.Am.Chem.Soc., 136, 2014
7K34
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BU of 7k34 by Molmil
Crystal structure of L-threonine transaldolase from Pseudomonas fluorescens in internal aldimine state
分子名称: SULFATE ION, Threonine aldolase
著者Kumar, P, Bingman, C.A, Buller, A.R.
登録日2020-09-10
公開日2020-12-30
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献l-Threonine Transaldolase Activity Is Enabled by a Persistent Catalytic Intermediate.
Acs Chem.Biol., 16, 2021
8SF4
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BU of 8sf4 by Molmil
Cystathionine gamma lyase from Thermobifida fusca in internal aldimine form
分子名称: Cystathionine gamma-lyase, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
著者Perkins, L.J, Buller, A.R, Bindman, C.A.
登録日2023-04-10
公開日2024-07-03
実験手法X-RAY DIFFRACTION (1.455 Å)
主引用文献Multiplexed deconvolution of enzyme function in a PLP-dependent protein family
To Be Published
7RNQ
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BU of 7rnq by Molmil
Holo structure of engineered TrpB, 2B9-H275E, from Pyrococcus furiosus in the extended-open conformation
分子名称: PHOSPHATE ION, SODIUM ION, Tryptophan synthase beta chain 1
著者Higgins, P.M, Buller, A.R.
登録日2021-07-29
公開日2022-08-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis.
Nat Commun, 13, 2022

 

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