6AM7

Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9

Summary for 6AM7

Entry DOI	10.2210/pdb6am7/pdb
Related	5VM5
Descriptor	Tryptophan synthase beta chain 1, SODIUM ION, PHOSPHATE ION, ... (4 entities in total)
Functional Keywords	plp type ii, tryptophan synthase, engineered, allostery, biosynthetic protein
Biological source	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Total number of polymer chains	4
Total formula weight	175015.69
Authors	Buller, A.R.,van Roye, P. (deposition date: 2017-08-09, release date: 2018-05-16, Last modification date: 2023-11-15)
Primary citation	Buller, A.R.,van Roye, P.,Cahn, J.K.B.,Scheele, R.A.,Herger, M.,Arnold, F.H. Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140:7256-7266, 2018 Cited by PubMed: 29712420 DOI: 10.1021/jacs.8b03490 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation