6AMI
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Trp non-covalently bound
Summary for 6AMI
Entry DOI | 10.2210/pdb6ami/pdb |
Related | 5VM5 6AM7 6AM8 6AM9 6AMC 6AMH |
Descriptor | Tryptophan synthase beta chain 1, TRYPTOPHAN, SODIUM ION, ... (4 entities in total) |
Functional Keywords | plp type ii, tryptophan synthase, engineered, allostery, biosynthetic protein |
Biological source | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) |
Total number of polymer chains | 4 |
Total formula weight | 175711.11 |
Authors | Buller, A.R. (deposition date: 2017-08-09, release date: 2018-05-16, Last modification date: 2022-03-23) |
Primary citation | Buller, A.R.,van Roye, P.,Cahn, J.K.B.,Scheele, R.A.,Herger, M.,Arnold, F.H. Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble. J. Am. Chem. Soc., 140:7256-7266, 2018 Cited by PubMed: 29712420DOI: 10.1021/jacs.8b03490 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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