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6AMH

Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB4D11 with Ser bound as E(Aex1)

Summary for 6AMH
Entry DOI10.2210/pdb6amh/pdb
Related5VM5 6AM7 6AM8 6AM9 6AMC
DescriptorTryptophan synthase beta chain 1, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, SODIUM ION, ... (4 entities in total)
Functional Keywordsplp type ii, tryptophan synthase, engineered, allostery, biosynthetic protein
Biological sourcePyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Total number of polymer chains4
Total formula weight175303.68
Authors
Buller, A.R. (deposition date: 2017-08-09, release date: 2018-05-16, Last modification date: 2023-10-04)
Primary citationBuller, A.R.,van Roye, P.,Cahn, J.K.B.,Scheele, R.A.,Herger, M.,Arnold, F.H.
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.
J. Am. Chem. Soc., 140:7256-7266, 2018
Cited by
PubMed: 29712420
DOI: 10.1021/jacs.8b03490
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.63 Å)
Structure validation

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