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1TXD
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BU of 1txd by Molmil
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF
分子名称: Rho guanine nucleotide exchange factor 12
著者Kristelly, R, Gao, G, Tesmer, J.J.
登録日2004-07-03
公開日2004-09-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
2ACX
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BU of 2acx by Molmil
Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP
分子名称: G protein-coupled receptor kinase 6, MAGNESIUM ION, PHOSPHATE ION, ...
著者Lodowski, D.T, Tesmer, V.M, Benovic, J.L, Tesmer, J.J.
登録日2005-07-19
公開日2006-04-25
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs.
J.Biol.Chem., 281, 2006
1X86
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BU of 1x86 by Molmil
Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA
分子名称: PHOSPHATE ION, Rho guanine nucleotide exchange factor 12, Transforming protein RhoA
著者Kristelly, R, Gao, G, Tesmer, J.J.
登録日2004-08-17
公開日2004-09-21
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (3.22 Å)
主引用文献Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
J.Biol.Chem., 279, 2004
3PSC
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BU of 3psc by Molmil
Bovine GRK2 in complex with Gbetagamma subunits
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-01
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVU
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BU of 3pvu by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
分子名称: 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-07
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3PVW
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BU of 3pvw by Molmil
Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD103A)
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Thal, D.M, Tesmer, J.J.
登録日2010-12-07
公開日2011-06-01
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors.
Mol.Pharmacol., 80, 2011
3KRW
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BU of 3krw by Molmil
Human GRK2 in complex with Gbetgamma subunits and balanol (soak)
分子名称: BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Tesmer, J.J.G, Tesmer, V.M.
登録日2009-11-19
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3KRX
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BU of 3krx by Molmil
Human GRK2 in complex with Gbetgamma subunits and balanol (co-crystal)
分子名称: BALANOL, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Tesmer, J.J.G, Tesmer, V.M.
登録日2009-11-19
公開日2010-02-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure of human g protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
3CIK
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BU of 3cik by Molmil
Human GRK2 in Complex with Gbetagamma subunits
分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Tesmer, J.J.G, Lodowski, D.T.
登録日2008-03-11
公開日2009-02-17
最終更新日2012-03-07
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
J.Med.Chem., 53, 2010
1GPM
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BU of 1gpm by Molmil
ESCHERICHIA COLI GMP SYNTHETASE COMPLEXED WITH AMP AND PYROPHOSPHATE
分子名称: ADENOSINE MONOPHOSPHATE, CITRIC ACID, GMP SYNTHETASE, ...
著者Tesmer, J.J.G.
登録日1995-04-04
公開日1996-01-29
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Nat.Struct.Biol., 3, 1996
1CJU
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BU of 1cju by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP AND MG
分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENYLATE CYCLASE, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJT
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BU of 1cjt by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MN, AND MG
分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJV
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BU of 1cjv by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH BETA-L-2',3'-DIDEOXYATP, MG, AND ZN
分子名称: 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1999-04-19
公開日1999-08-31
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
1CJK
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COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH ADENOSINE 5'-(ALPHA THIO)-TRIPHOSPHATE (RP), MG, AND MN
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1999-04-16
公開日1999-08-31
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-metal-Ion catalysis in adenylyl cyclase.
Science, 285, 1999
3T8O
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BU of 3t8o by Molmil
Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GLYCEROL, ...
著者Tesmer, J.J.G, Singh, P, Nance, M.R.
登録日2011-08-01
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of a monomeric variant of rhodopsin kinase at 2.5 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
1CS4
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BU of 1cs4 by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, PYROPHOSPHATE AND MG
分子名称: 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R.
登録日1999-08-16
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1CUL
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BU of 1cul by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE: COMPLEX WITH 2',5'-DIDEOXY-ADENOSINE 3'-TRIPHOSPHATE AND MG
分子名称: 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
著者Tesmer, J.J.G, Dessauer, C.A, Sunahara, R.K, Johnson, R.A, Gilman, A.G, Sprang, S.R.
登録日1999-08-20
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular basis for P-site inhibition of adenylyl cyclase.
Biochemistry, 39, 2000
1AGR
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BU of 1agr by Molmil
COMPLEX OF ALF4-ACTIVATED GI-ALPHA-1 WITH RGS4
分子名称: CITRIC ACID, GUANINE NUCLEOTIDE-BINDING PROTEIN G(I), GUANOSINE-5'-DIPHOSPHATE, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1997-03-25
公開日1997-06-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.
Cell(Cambridge,Mass.), 89, 1997
1AZS
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BU of 1azs by Molmil
COMPLEX OF GS-ALPHA WITH THE CATALYTIC DOMAINS OF MAMMALIAN ADENYLYL CYCLASE
分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GS-ALPHA, IIC2, ...
著者Tesmer, J.J.G, Sprang, S.R.
登録日1997-11-20
公開日1998-02-25
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Science, 278, 1997
5FI1
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BU of 5fi1 by Molmil
Crystal Structure of the P-Rex1 DH/PH tandem in complex with Cdc42
分子名称: Cell division control protein 42 homolog, Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein,Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
著者Cash, J.N, Tesmer, J.J.G.
登録日2015-12-22
公開日2016-04-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.203 Å)
主引用文献Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Structure, 24, 2016
9ABP
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BU of 9abp by Molmil
A PRO TO GLY MUTATION IN THE HINGE OF THE ARABINOSE-BINDING PROTEIN ENHANCES BINDING AND ALTERS SPECIFICITY: SUGAR-BINDING AND CRYSTALLOGRAPHIC STUDIES
分子名称: L-ARABINOSE-BINDING PROTEIN, alpha-D-galactopyranose, beta-D-galactopyranose
著者Vermersch, P.S, Tesmer, J.J.G, Quiocho, F.A.
登録日1991-11-15
公開日1992-01-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献A Pro to Gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity. Sugar-binding and crystallographic studies.
J.Biol.Chem., 265, 1990
3C50
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Crystal Structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 2.6A
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ...
著者Singh, P, Tesmer, J.J.G.
登録日2008-01-30
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C4Y
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Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A
分子名称: Rhodopsin kinase
著者Singh, P, Tesmer, J.J.G.
登録日2008-01-30
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (7.509 Å)
主引用文献Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C51
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Crystal structure of G protein coupled receptor kinase 1 bound to ADP and magnesium chloride at 3.55A
分子名称: ADENOSINE-5'-DIPHOSPHATE, BROMIDE ION, MAGNESIUM ION, ...
著者Singh, P, Tesmer, J.J.G.
登録日2008-01-30
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008
3C4X
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Crystal Structure of G protein coupled receptor kinase 1 bound to ATP and magnesium chloride at 2.9A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Singh, P, Tesmer, J.J.G.
登録日2008-01-30
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation.
J.Biol.Chem., 283, 2008

 

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