4N75
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5QCK
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![BU of 5qck by Molmil](/molmil-images/mine/5qck) | FACTOR XIA IN COMPLEX WITH THE INHIBITOR 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3-phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid | 分子名称: | 1,2-ETHANEDIOL, 4-[[(2~{S},3~{R})-1-[(~{E})-3-[5-chloranyl-2-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3-phenyl-pyrrolidin-2-yl]carbonylamino]benzoic acid, Coagulation factor XI, ... | 著者 | Sheriff, S. | 登録日 | 2017-08-10 | 公開日 | 2017-11-08 | 最終更新日 | 2018-02-21 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). J. Med. Chem., 60, 2017
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5QCM
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![BU of 5qcm by Molmil](/molmil-images/mine/5qcm) | FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[[(1~{S})-2-[(~{E})-3-[3-chloranyl-2-fluoranyl-6-(1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoyl]-3,4-dihydro-1~{H}-isoquinolin-1-yl]carbonylamino]phenyl]carbamate | 分子名称: | 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... | 著者 | Sheriff, S. | 登録日 | 2017-08-10 | 公開日 | 2017-11-08 | 最終更新日 | 2018-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212). J. Med. Chem., 60, 2017
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5I3U
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![BU of 5i3u by Molmil](/molmil-images/mine/5i3u) | |
4LI0
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![BU of 4li0 by Molmil](/molmil-images/mine/4li0) | Crystal structure of GDP-bound Rab8:GRAB | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide exchange factor for Rab-3A, Ras-related protein Rab-8A | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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4LHW
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![BU of 4lhw by Molmil](/molmil-images/mine/4lhw) | Crystal structure of Rab8 in its active GppNHp-bound form | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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4LHX
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![BU of 4lhx by Molmil](/molmil-images/mine/4lhx) | Crystal structure of nucleotide-free Rab8:Rabin8 | 分子名称: | Rab-3A-interacting protein, Ras-related protein Rab-8A, SULFATE ION | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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4LHV
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![BU of 4lhv by Molmil](/molmil-images/mine/4lhv) | Crystal structure of Rab8 in its inactive GDP-bound form | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-8A | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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4LHZ
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![BU of 4lhz by Molmil](/molmil-images/mine/4lhz) | Crystal structure of GTP-bound Rab8:Rabin8 | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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4LHY
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![BU of 4lhy by Molmil](/molmil-images/mine/4lhy) | Crystal structure of GDP-bound Rab8:Rabin8 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Rab-3A-interacting protein, Ras-related protein Rab-8A, ... | 著者 | Guo, Z, Hou, X.M, Goody, R.S, Itzen, A. | 登録日 | 2013-07-01 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRAB. J.Biol.Chem., 288, 2013
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7WZX
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![BU of 7wzx by Molmil](/molmil-images/mine/7wzx) | The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | (2~{S},4~{S},6~{R})-2-[(2~{S},3~{R},5~{S},6~{R})-3,5-bis(methylamino)-2,4,6-tris(oxidanyl)cyclohexyl]oxy-6-methyl-4-oxidanyl-oxan-3-one, 4Fe-4S cluster-binding domain-containing protein, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2022-02-19 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.980013 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
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7WZV
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![BU of 7wzv by Molmil](/molmil-images/mine/7wzv) | The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ... | 著者 | Zhou, J.H, Hou, X.L. | 登録日 | 2022-02-19 | 公開日 | 2022-12-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.899313 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
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7X0B
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![BU of 7x0b by Molmil](/molmil-images/mine/7x0b) | The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | 4Fe-4S cluster-binding domain-containing protein, CHLORIDE ION, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2022-02-21 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.02027535 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
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7W8L
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![BU of 7w8l by Molmil](/molmil-images/mine/7w8l) | Crystal Structure of Co-type nitrile hydratase mutant from Pseudonocardia thermophila - M46R | 分子名称: | COBALT (II) ION, Cobalt-containing nitrile hydratase subunit beta, Nitrile hydratase | 著者 | Ma, D, Cheng, Z.Y, Hou, X.D, Peplowski, L, Lai, Q.P, Fu, K, Yin, D.J, Rao, Y.J, Zhou, Z.M. | 登録日 | 2021-12-08 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Insight into the broadened substrate scope of nitrile hydratase by static and dynamic structure analysis. Chem Sci, 13, 2022
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7W8M
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![BU of 7w8m by Molmil](/molmil-images/mine/7w8m) | Crystal structure of Co-type nitrile hydratase mutant from Pseudomonas thermophila - A129R | 分子名称: | COBALT (II) ION, Cobalt-containing nitrile hydratase subunit beta, Nitrile hydratase | 著者 | Ma, D, Cheng, Z.Y, Hou, X.D, Peplowski, L, Lai, Q.P, Fu, K, Yin, D.J, Rao, Y.J, Zhou, Z.M. | 登録日 | 2021-12-08 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Insight into the broadened substrate scope of nitrile hydratase by static and dynamic structure analysis. Chem Sci, 13, 2022
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8G9S
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![BU of 8g9s by Molmil](/molmil-images/mine/8g9s) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | AcrIC8, Cas11, Cas5, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9T
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![BU of 8g9t by Molmil](/molmil-images/mine/8g9t) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | AcrIC9, Cas11, Cas5, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8G9U
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![BU of 8g9u by Molmil](/molmil-images/mine/8g9u) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | CRISPR-associated protein, Csd1 family, Csd2 family, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAF
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![BU of 8gaf by Molmil](/molmil-images/mine/8gaf) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-22 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAM
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![BU of 8gam by Molmil](/molmil-images/mine/8gam) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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8GAN
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![BU of 8gan by Molmil](/molmil-images/mine/8gan) | Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications | 分子名称: | Cas11, Cas5, Cas7, ... | 著者 | Hu, C, Nam, K.H, Ke, A. | 登録日 | 2023-02-23 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
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7FDZ
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![BU of 7fdz by Molmil](/molmil-images/mine/7fdz) | Levansucrase from Brenneria sp. EniD 312 with sucrose | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Xu, W, Hou, X.D, Rao, Y.J, Pijning, T, Guskov, A, Mu, W.M. | 登録日 | 2021-07-19 | 公開日 | 2022-04-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal Structure of Levansucrase from the Gram-Negative Bacterium Brenneria Provides Insights into Its Product Size Specificity. J.Agric.Food Chem., 70, 2022
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7EYO
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![BU of 7eyo by Molmil](/molmil-images/mine/7eyo) | Crystal structure of leech hyaluronidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hyaluronoglucuronidase | 著者 | Huang, H, Hou, X.D, Rao, Y.J, Kang, Z. | 登録日 | 2021-05-31 | 公開日 | 2022-05-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure and cleavage pattern of a hyaluronate 3-glycanohydrolase in the glycoside hydrolase 79 family. Carbohydr Polym, 277, 2022
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3E3R
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![BU of 3e3r by Molmil](/molmil-images/mine/3e3r) | |
5TXP
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![BU of 5txp by Molmil](/molmil-images/mine/5txp) | STRUCTURE OF Q151M complex (A62V, V75I, F77L, F116Y, Q151M) mutant HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP | 分子名称: | 1,2-ETHANEDIOL, 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), ... | 著者 | Das, K, Martinez, S.M, Arnold, E. | 登録日 | 2016-11-17 | 公開日 | 2017-04-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. Antimicrob. Agents Chemother., 61, 2017
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