5I3U

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE N-SITE COMPLEX; CATALYTIC INCORPORATION OF AZTMP to A DNA aptamer in CRYSTAL

Summary for 5I3U

• Entry DOI: 10.2210/pdb5i3u/pdb
• Related: 5D3G 5HP1 5HRO 5I42
• Related PRD ID: PRD_900003
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (39-MER), ... (6 entities in total)
• Functional Keywords: rt, dna aptamer, foscavir, n site complex, pyrophosphate, pyrophosphorolysis, phosphonoformic acid, pfa, 2-o-methylcytidine, p51, p66, transferase, transferase-dna complex, transferase/dna
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); More
• Total number of polymer chains: 6
• Total formula weight: 256680.35

Authors

Das, K.,Arnold, E. (deposition date: 2016-02-11, release date: 2016-06-01, Last modification date: 2023-09-27)

• Primary citation: Das, K.,Balzarini, J.,Miller, M.T.,Maguire, A.R.,DeStefano, J.J.,Arnold, E.; Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.; Acs Chem.Biol., 11:2158-2164, 2016; PubMed: 27192549; DOI: 10.1021/acschembio.6b00187

Experimental method

X-RAY DIFFRACTION (3 Å)