2FNO
 
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5XEZ
 | | Structure of the Full-length glucagon class B G protein-coupled receptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide, ... | | 著者 | Zhang, H, Qiao, A, Yang, D, Yang, L, Dai, A, de Graaf, C, Reedtz-Runge, S, Dharmarajan, V, Zhang, H, Han, G.W, Grant, T, Sierra, R, Weierstall, U, Nelson, G, Liu, W, Wu, Y, Ma, L, Cai, X, Lin, G, Wu, X, Geng, Z, Dong, Y, Song, G, Griffin, P, Lau, J, Cherezov, V, Yang, H, Hanson, M, Stevens, R, Jiang, H, Wang, M, Zhao, Q, Wu, B. | | 登録日 | 2017-04-06 | | 公開日 | 2017-05-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the full-length glucagon class B G-protein-coupled receptor.
Nature, 546, 2017
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5YQZ
 | | Structure of the glucagon receptor in complex with a glucagon analogue | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon analogue, ... | | 著者 | Zhang, H, Qiao, A, Yang, L, VAN EPS, N, Frederiksen, K, Yang, D, Dai, A, Cai, X, Zhang, H, Yi, C, Can, C, He, L, Yang, H, Lau, J, Ernst, O, Hanson, M, Stevens, R, Wang, M, Seedtz-Runge, S, Jiang, H, Zhao, Q, Wu, B. | | 登録日 | 2017-11-08 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
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3AT1
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7SUS
 | | Crystal structure of Apelin receptor in complex with small molecule | | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor, ... | | 著者 | Xu, F, Yue, Y, Liu, L.E, Han, G.W, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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2AT1
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5ERA
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5ER7
 | | Connexin-26 Bound to Calcium | | 分子名称: | CALCIUM ION, Gap junction beta-2 protein | | 著者 | Purdy, M.D, Bennett, B.C, Baker, K.A, Yeager, M.J. | | 登録日 | 2015-11-13 | | 公開日 | 2016-01-27 | | 最終更新日 | 2019-12-04 | | 実験手法 | X-RAY DIFFRACTION (3.286 Å) | | 主引用文献 | An electrostatic mechanism for Ca(2+)-mediated regulation of gap junction channels.
Nat Commun, 7, 2016
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6EDR
 | | Crystal Structure of Human CD38 in Complex with 4'-Thioribose NAD+ | | 分子名称: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3,4-bis(oxidanyl)thiolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | 著者 | Dai, Z, Zhang, X.N, Nasertorabi, F, Cheng, Q, Pei, H, Louie, S.G, Stevens, C.R, Zhang, Y. | | 登録日 | 2018-08-10 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Facile chemoenzymatic synthesis of a novel stable mimic of NAD.
Chem Sci, 9, 2018
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5ZKQ
 | | Crystal structure of the human platelet-activating factor receptor in complex with ABT-491 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, ... | | 著者 | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | | 登録日 | 2018-03-25 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
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5ZBH
 | | The Crystal Structure of Human Neuropeptide Y Y1 Receptor with BMS-193885 | | 分子名称: | Neuropeptide Y receptor type 1,T4 Lysozyme,Neuropeptide Y receptor type 1, dimethyl 4-{3-[({3-[4-(3-methoxyphenyl)piperidin-1-yl]propyl}carbamoyl)amino]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | | 著者 | Yang, Z, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2018-02-11 | | 公開日 | 2018-04-25 | | 最終更新日 | 2018-05-09 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural basis of ligand binding modes at the neuropeptide Y Y1receptor
Nature, 556, 2018
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5ZBQ
 | | The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299 | | 分子名称: | Neuropeptide Y receptor type 1,T4 Lysozyme, N~2~-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-N~5~-(N'-{[2-(propanoylamino)ethyl]carbamoyl}carbamimidoyl)-D-ornithinamide | | 著者 | Yang, Z, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2018-02-12 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis of ligand binding modes at the neuropeptide Y Y1receptor
Nature, 556, 2018
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5ZKP
 | | Crystal structure of the human platelet-activating factor receptor in complex with SR 27417 | | 分子名称: | FLAVIN MONONUCLEOTIDE, N1,N1-dimethyl-N2-[(pyridin-3-yl)methyl]-N2-{4-[2,4,6-tri(propan-2-yl)phenyl]-1,3-thiazol-2-yl}ethane-1,2-diamine, Platelet-activating factor receptor,Flavodoxin,Platelet-activating factor receptor | | 著者 | Cao, C, Zhao, Q, Zhang, X.C, Wu, B. | | 登録日 | 2018-03-25 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25, 2018
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5ZTY
 | | Crystal structure of human G protein coupled receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Li, X.T, Hua, T, Wu, L.J, Liu, Z.J. | | 登録日 | 2018-05-05 | | 公開日 | 2019-01-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of the Human Cannabinoid Receptor CB2
Cell, 176, 2019
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4ZJ2
 | | Crystal Structure of p-acrylamido-phenylalanine modified TEM1 beta-lactamase from Escherichia coli :E166N mutant | | 分子名称: | Beta-lactamase TEM | | 著者 | Xiao, H, Nasertorabi, F, Choi, S, Han, G.W, Reed, S.A, Stevens, C.S, Schultz, P.G. | | 登録日 | 2015-04-28 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Exploring the potential impact of an expanded genetic code on protein function.
Proc.Natl.Acad.Sci.USA, 112, 2015
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6J20
 | | Crystal structure of the human NK1 substance P receptor | | 分子名称: | 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, Substance-P receptor,Endolysin | | 著者 | Chen, S, Lu, M, Zhang, H, Wu, B, Zhao, Q. | | 登録日 | 2018-12-30 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
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6J21
 | | Crystal structure of the human NK1 substance P receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-[[(2~{R},3~{S})-2-[(1~{R})-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one, Substance-P receptor,Endolysin | | 著者 | Chen, S, Lu, M, Zhang, H, Wu, B, Zhao, Q. | | 登録日 | 2018-12-30 | | 公開日 | 2019-03-06 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography.
Nat Commun, 10, 2019
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3QAK
 | | Agonist bound structure of the human adenosine A2a receptor | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, Adenosine receptor A2a,lysozyme chimera | | 著者 | Xu, F, Wu, H, Katritch, V, Han, G.W, Cherezov, V, Stevens, R, GPCR Network (GPCR) | | 登録日 | 2011-01-11 | | 公開日 | 2011-03-09 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Structure of an agonist-bound human A2A adenosine receptor.
Science, 332, 2011
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3RZE
 | | Structure of the human histamine H1 receptor in complex with doxepin | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (3E)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, (3Z)-3-(dibenzo[b,e]oxepin-11(6H)-ylidene)-N,N-dimethylpropan-1-amine, ... | | 著者 | Shimamura, T, Han, G.W, Shiroishi, M, Weyand, S, Tsujimoto, H, Winter, G, Katritch, V, Abagyan, R, Cherezov, V, Liu, W, Kobayashi, T, Stevens, R, Iwata, S, GPCR Network (GPCR) | | 登録日 | 2011-05-11 | | 公開日 | 2011-06-15 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure of the human histamine H1 receptor complex with doxepin.
Nature, 475, 2011
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2B8N
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2FE8
 | | SARS coronavirus papain-like protease: structure of a viral deubiquitinating enzyme | | 分子名称: | BROMIDE ION, Replicase polyprotein 1ab, SULFATE ION, ... | | 著者 | Ratia, K, Santarsiero, B.D, Mesecar, A.D. | | 登録日 | 2005-12-15 | | 公開日 | 2006-03-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
Proc.Natl.Acad.Sci.Usa, 103, 2006
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5VBL
 | | Structure of apelin receptor in complex with agonist peptide | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ... | | 著者 | Ma, Y, Yue, Y, Ma, Y, Zhang, Q, Zhou, Q, Song, Y, Shen, Y, Li, X, Ma, X, Li, C, Hanson, M.A, Han, G.W, Sickmier, E.A, Swaminath, G, Zhao, S, Stevems, R.C, Hu, L.A, Zhong, W, Zhang, M, Xu, F. | | 登録日 | 2017-03-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Basis for Apelin Control of the Human Apelin Receptor
Structure, 25, 2017
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5DGY
 | | Crystal structure of rhodopsin bound to visual arrestin | | 分子名称: | Endolysin,Rhodopsin,S-arrestin | | 著者 | Zhou, X.E, Gao, X, Kang, Y, He, Y, de Waal, P.W, Suino-Powell, K.M, Wang, M, Melcher, K, Xu, H.E. | | 登録日 | 2015-08-28 | | 公開日 | 2016-03-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (7.7 Å) | | 主引用文献 | X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.
Sci Data, 3, 2016
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7W0M
 | | Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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7W0N
 | | Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | | 登録日 | 2021-11-18 | | 公開日 | 2022-07-27 | | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry.
Nat.Struct.Mol.Biol., 29, 2022
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