8WQA
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![BU of 8wqa by Molmil](/molmil-images/mine/8wqa) | Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1) | 分子名称: | Coiled-coil domain-containing protein 89, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Chen, X, Zhang, K, Xu, C. | 登録日 | 2023-10-11 | 公開日 | 2024-04-03 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15, 2024
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4L7I
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![BU of 4l7i by Molmil](/molmil-images/mine/4l7i) | Crystal structure of S-Adenosylmethionine synthase from Sulfolobus solfataricus complexed with SAM and PPi | 分子名称: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2013-06-13 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.189 Å) | 主引用文献 | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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4LCG
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![BU of 4lcg by Molmil](/molmil-images/mine/4lcg) | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-050 complex | 分子名称: | (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-L-tyrosinamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2013-06-21 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.568 Å) | 主引用文献 | Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56, 2013
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4MO7
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![BU of 4mo7 by Molmil](/molmil-images/mine/4mo7) | |
4KVN
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![BU of 4kvn by Molmil](/molmil-images/mine/4kvn) | Crystal structure of Fab 39.29 in complex with Influenza Hemagglutinin A/Perth/16/2009 (H3N2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Fong, R, Swem, L.R, Lupardus, P.J. | 登録日 | 2013-05-22 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A Novel In vivo Human Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Anti-Influenza A Antibodies Cell Host Microbe, 14, 2013
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2JZ3
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![BU of 2jz3 by Molmil](/molmil-images/mine/2jz3) | SOCS box elonginBC ternary complex | 分子名称: | Suppressor of cytokine signaling 3, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2 | 著者 | Babon, J.J, Sabo, J, Soetopo, A, Yao, S, Bailey, M.F, Zhang, J, Nicola, N.A, Norton, R.S. | 登録日 | 2007-12-27 | 公開日 | 2008-09-23 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase J.Mol.Biol., 381, 2008
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5IN9
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![BU of 5in9 by Molmil](/molmil-images/mine/5in9) | Crystal structure of Grp94 bound to methyl 3-chloro-2-(2-(1-((5-chlorofuran-2-yl)methyl)-1H-imidazol-2-yl)ethyl)-4,6-dihydroxybenzoate, an inhibitor based on the BnIm and Radamide scaffolds. | 分子名称: | Endoplasmin, GLYCEROL, TRIETHYLENE GLYCOL, ... | 著者 | Lieberman, R.L, Huard, D.J.E, Kizziah, J.L. | 登録日 | 2016-03-07 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold. J.Med.Chem., 59, 2016
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5V2R
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![BU of 5v2r by Molmil](/molmil-images/mine/5v2r) | |
4L2Z
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![BU of 4l2z by Molmil](/molmil-images/mine/4l2z) | Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAE and PPi | 分子名称: | DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Wang, F, Hurley, K.A, Helmich, K.E, Singh, S, Bingman, C.A, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | 登録日 | 2013-06-05 | 公開日 | 2013-06-19 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.494 Å) | 主引用文献 | Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281, 2014
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4LCH
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![BU of 4lch by Molmil](/molmil-images/mine/4lch) | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-051 complex | 分子名称: | (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-beta-methyl-L-tyrosinamide, NITRATE ION, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2013-06-21 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.596 Å) | 主引用文献 | Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56, 2013
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4LCF
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![BU of 4lcf by Molmil](/molmil-images/mine/4lcf) | Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex | 分子名称: | NITRATE ION, Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-histidinamide, UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ... | 著者 | Lee, C.-J, Zhou, P. | 登録日 | 2013-06-21 | 公開日 | 2013-08-21 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56, 2013
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6JNM
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![BU of 6jnm by Molmil](/molmil-images/mine/6jnm) | REF6 ZnF2-4-NAC004-mC3 complex | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*GP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*(5CM)P*TP*GP*TP*TP*TP*TP*G)-3'), Lysine-specific demethylase REF6, ... | 著者 | Yao, Q.Q, Wu, B.X, Ma, J.B. | 登録日 | 2019-03-17 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | DNA methylation repels targeting of Arabidopsis REF6. Nat Commun, 10, 2019
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6JNN
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![BU of 6jnn by Molmil](/molmil-images/mine/6jnn) | REF6 ZnF2-4-NAC004-mC1 complex | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*CP*AP*GP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*(5CM)P*TP*CP*TP*GP*TP*TP*TP*TP*G)-3'), Lysine-specific demethylase REF6, ... | 著者 | Yao, Q.Q, Wu, B.X, Ma, J.B. | 登録日 | 2019-03-17 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | DNA methylation repels targeting of Arabidopsis REF6. Nat Commun, 10, 2019
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8IK2
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![BU of 8ik2 by Molmil](/molmil-images/mine/8ik2) | RhlA exhibits dual thioesterase and acyltransferase activities during rhamnolipid biosynthesis | 分子名称: | (3~{S})-3-oxidanyldecanoic acid, 3-(3-hydroxydecanoyloxy)decanoate synthase | 著者 | Tang, T, Fu, L.H, Xie, W.H, Luo, Y.Z, Zhang, Y.T, Si, T. | 登録日 | 2023-02-28 | 公開日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | RhlA Exhibits Dual Thioesterase and Acyltransferase Activities during Rhamnolipid Biosynthesis Acs Catalysis, 13, 2023
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6UM5
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![BU of 6um5 by Molmil](/molmil-images/mine/6um5) | Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Acharya, P, Henderson, R.C, Saunders, K.O, Haynes, B.F. | 登録日 | 2019-10-09 | 公開日 | 2019-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science, 366, 2019
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4QVC
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![BU of 4qvc by Molmil](/molmil-images/mine/4qvc) | E.coli Hfq in complex with RNA Aus | 分子名称: | RNA (5'-R(*AP*U*AP*AP*CP*UP*A)-3'), RNA-binding protein Hfq | 著者 | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | 登録日 | 2014-07-14 | 公開日 | 2015-05-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq Nucleic Acids Res., 43, 2015
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6UM6
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![BU of 6um6 by Molmil](/molmil-images/mine/6um6) | Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Acharya, P, Henderson, R.C, Saunder, K.O, Haynes, B.F. | 登録日 | 2019-10-09 | 公開日 | 2019-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science, 366, 2019
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6UM7
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![BU of 6um7 by Molmil](/molmil-images/mine/6um7) | Cryo-EM structure of vaccine-elicited HIV-1 neutralizing antibody DH270.mu1 in complex with CH848 10.17DT Env | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH270.mu1 Fab Heavy Chain, DH270.mu1 Fab Light chain, ... | 著者 | Acharya, P, Henderson, R.C, Saunders, K, Haynes, B.F. | 登録日 | 2019-10-09 | 公開日 | 2019-12-18 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Targeted selection of HIV-specific antibody mutations by engineering B cell maturation. Science, 366, 2019
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7DK2
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![BU of 7dk2 by Molmil](/molmil-images/mine/7dk2) | Crystal structure of SARS-CoV-2 Spike RBD in complex with MW07 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MW07 heavy chain, MW07 light chain, ... | 著者 | Wang, J, Jiao, S, Wang, R, Zhang, J, Zhang, M, Wang, M, Chen, S. | 登録日 | 2020-11-22 | 公開日 | 2021-12-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Architectural versatility of spike neutralization by a SARS-CoV-2 antibody To Be Published
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6KVE
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![BU of 6kve by Molmil](/molmil-images/mine/6kve) | |
4QVD
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![BU of 4qvd by Molmil](/molmil-images/mine/4qvd) | E.coli Hfq in complex with RNA Ads | 分子名称: | RNA (5'-R(*AP*AP*CP*UP*AP*AP*A)-3'), RNA-binding protein Hfq | 著者 | Wang, L.J, Wang, W.W, Li, F.D, Wu, J.H, Gong, Q.G, Shi, Y.Y. | 登録日 | 2014-07-14 | 公開日 | 2015-05-27 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.972 Å) | 主引用文献 | Structural insights into the recognition of the internal A-rich linker from OxyS sRNA by Escherichia coli Hfq Nucleic Acids Res., 43, 2015
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6KVH
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![BU of 6kvh by Molmil](/molmil-images/mine/6kvh) | The mutant crystal structure of endo-polygalacturonase (T284A) from Talaromyces leycettanus JCM 12802 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, endo-polygalacturonase | 著者 | Tu, T, Wang, Z, Luo, H, Yao, B. | 登録日 | 2019-09-04 | 公開日 | 2020-09-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural Insights into the Mechanisms Underlying the Kinetic Stability of GH28 Endo-Polygalacturonase. J.Agric.Food Chem., 69, 2021
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4DCH
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![BU of 4dch by Molmil](/molmil-images/mine/4dch) | Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations | 分子名称: | (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, Glucokinase, IODIDE ION, ... | 著者 | Greasley, S.E, Hickey, M, Feng, J, Garcia, E. | 登録日 | 2012-01-17 | 公開日 | 2012-02-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
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2JG4
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![BU of 2jg4 by Molmil](/molmil-images/mine/2jg4) | Substrate-free IDE structure in its closed conformation | 分子名称: | 1,4-DIETHYLENE DIOXIDE, INSULIN DEGRADING ENZYME, ZINC ION | 著者 | Malito, E, Tang, W.J. | 登録日 | 2007-02-07 | 公開日 | 2007-07-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide J.Biol.Chem., 282, 2007
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4RSE
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![BU of 4rse by Molmil](/molmil-images/mine/4rse) | Crystal structure of RPE65 in complex with MB-001 and palmitate | 分子名称: | (1R)-3-amino-1-{3-[(2,6,6-trimethylcyclohex-1-en-1-yl)methoxy]phenyl}propan-1-ol, FE (II) ION, PALMITIC ACID, ... | 著者 | Kiser, P.D, Shi, W, Palczewski, K. | 登録日 | 2014-11-07 | 公開日 | 2015-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat.Chem.Biol., 11, 2015
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