4DCH
Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations
Summary for 4DCH
Entry DOI | 10.2210/pdb4dch/pdb |
Descriptor | Glucokinase, alpha-D-glucopyranose, (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide, ... (5 entities in total) |
Functional Keywords | gk beta cell, small molecule, open conformation, kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 54142.03 |
Authors | Greasley, S.E.,Hickey, M.,Feng, J.,Garcia, E. (deposition date: 2012-01-17, release date: 2012-02-08, Last modification date: 2024-02-28) |
Primary citation | Liu, S.,Ammirati, M.J.,Song, X.,Knafels, J.D.,Zhang, J.,Greasley, S.E.,Pfefferkorn, J.A.,Qiu, X. Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287:13598-13610, 2012 Cited by PubMed: 22298776DOI: 10.1074/jbc.M111.274126 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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