4DCH
Insights into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glucokinase | polymer | 473 | 53329.6 | 1 | UniProt (P35557) Pfam (PF00349) Pfam (PF03727) In PDB | Homo sapiens (human) | Hexokinase type IV, HK IV, Hexokinase-4, HK4, Hexokinase-D |
| 2 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 3 | A | (2R)-3-cyclopentyl-2-[4-(methylsulfonyl)phenyl]-N-(1,3-thiazol-2-yl)propanamide | non-polymer | 378.5 | 1 | Chemie (4DC) | |||
| 4 | A | IODIDE ION | non-polymer | 126.9 | 2 | Chemie (IOD) | |||
| 5 | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A: 1 - 465 (UniProt: P35557)
| PDB | External Database | Details |
|---|---|---|
| Leu 466 | - | expression tag |
| Glu 467 | - | expression tag |
| His 468 | - | expression tag |
| His 469 | - | expression tag |
| His 470 | - | expression tag |
| His 471 | - | expression tag |
| His 472 | - | expression tag |
| His 473 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53329.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 812.5 | |
| All* | Total formula weight | 54142.0 |
