4L2Z

Crystal structure of S-Adenosylmethionine synthetase from Sulfolobus solfataricus complexed with SAE and PPi

Summary for 4L2Z

Entry DOI	10.2210/pdb4l2z/pdb
Related	4HPV 4K0B 4L7I
Descriptor	S-adenosylmethionine synthase, MAGNESIUM ION, [(3S)-3-amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}ethyls ulfonium, ... (6 entities in total)
Functional Keywords	structural genomics, psi-biology, protein structure initiative, enzyme discovery for natural product biosynthesis, natpro, s-adenosylmethionine synthase, transferase
Biological source	Sulfolobus solfataricus
Total number of polymer chains	2
Total formula weight	91392.36
Authors	Wang, F.,Hurley, K.A.,Helmich, K.E.,Singh, S.,Bingman, C.A.,Thorson, J.S.,Phillips Jr., G.N.,Enzyme Discovery for Natural Product Biosynthesis (NatPro) (deposition date: 2013-06-05, release date: 2013-06-19, Last modification date: 2023-12-06)
Primary citation	Wang, F.,Singh, S.,Zhang, J.,Huber, T.D.,Helmich, K.E.,Sunkara, M.,Hurley, K.A.,Goff, R.D.,Bingman, C.A.,Morris, A.J.,Thorson, J.S.,Phillips, G.N. Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. Febs J., 281:4224-4239, 2014 Cited by PubMed: 24649856 DOI: 10.1111/febs.12784 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.494 Å)

Structure validation