4LCH
Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-051 complex
Summary for 4LCH
| Entry DOI | 10.2210/pdb4lch/pdb |
| Related | 4LCF 4LCG |
| Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (betaS)-Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N,beta-dihydroxy-beta-methyl-L-tyrosinamide, ... (5 entities in total) |
| Functional Keywords | lipid a biosynthesis, lipid a synthesis, baab sandwich, lpxc, deacetylation, acyl udp-glcnac, hydroxamate, hydrolase-antibiotic complex, hydrolase/antibiotic |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 1 |
| Total formula weight | 34804.41 |
| Authors | Lee, C.-J.,Zhou, P. (deposition date: 2013-06-21, release date: 2013-08-21, Last modification date: 2024-02-28) |
| Primary citation | Liang, X.,Lee, C.J.,Zhao, J.,Toone, E.J.,Zhou, P. Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors. J.Med.Chem., 56:6954-6966, 2013 Cited by PubMed: 23914798DOI: 10.1021/jm4007774 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.596 Å) |
Structure validation
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