6UM6

Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env

Summary for 6UM6

• Entry DOI: 10.2210/pdb6um6/pdb
• EMDB information: 20818
• Descriptor: CH848 10.17DT gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 10.17DT gp41, ... (10 entities in total)
• Functional Keywords: v3-glycan site, unmutated common ancestor, dh270 lineage, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 12
• Total formula weight: 368764.46

Authors

Acharya, P.,Henderson, R.C.,Saunder, K.O.,Haynes, B.F. (deposition date: 2019-10-09, release date: 2019-12-18, Last modification date: 2020-07-29)

• Primary citation: Saunders, K.O.,Wiehe, K.,Tian, M.,Acharya, P.,Bradley, T.,Alam, S.M.,Go, E.P.,Scearce, R.,Sutherland, L.,Henderson, R.,Hsu, A.L.,Borgnia, M.J.,Chen, H.,Lu, X.,Wu, N.R.,Watts, B.,Jiang, C.,Easterhoff, D.,Cheng, H.L.,McGovern, K.,Waddicor, P.,Chapdelaine-Williams, A.,Eaton, A.,Zhang, J.,Rountree, W.,Verkoczy, L.,Tomai, M.,Lewis, M.G.,Desaire, H.R.,Edwards, R.J.,Cain, D.W.,Bonsignori, M.,Montefiori, D.,Alt, F.W.,Haynes, B.F.; Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.; Science, 366:-, 2019; PubMed: 31806786; DOI: 10.1126/science.aay7199

Experimental method

ELECTRON MICROSCOPY (4.3 Å)