6UM6
Cryo-EM structure of HIV-1 neutralizing antibody DH270.6 in complex with CH848 10.17DT Env
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (A, E, I) | CH848 10.17DT gp120 | polymer | 463 | 51736.5 | 3 | UniProt (A0A1W6IPB2) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | B, F, J (B, F, J) | CH848 10.17DT gp41 | polymer | 161 | 18245.8 | 3 | UniProt (Q2N0S7) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | C, G, K (C, G, K) | DH270.6 Heavy chain | polymer | 238 | 25895.9 | 3 | Homo sapiens (Human) | ||
| 4 | D, H, L (D, H, L) | DH270.6 Light chain | polymer | 216 | 22783.3 | 3 | Homo sapiens (Human) | ||
| 5 | M, R, W (M, R, W) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
| 6 | N, S, X (N, S, X) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G35932AR) | |||
| 7 | O, T, Y (O, T, Y) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 8 | P, U, Z (P, U, Z) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 9 | AA, Q, V (a, Q, V) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 10 | BA, CA, DA, EA, FA... (A, E, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 18 | Chemie (NAG) |
Sequence modifications
A, E, I: 34 - 505 (UniProt: A0A1W6IPB2)
B, F, J: 511 - 664 (UniProt: Q2N0S7)
| PDB | External Database | Details |
|---|---|---|
| Ala 31 | - | expression tag |
| Glu 32 | - | expression tag |
| Asn 33 | - | expression tag |
| Asp 133 | Asn 129 | conflict |
| Thr 138 | Asn 134 | conflict |
| Cys 201 | Val 189 | conflict |
| Cys 433 | Ala 417 | conflict |
| Lys 490 | Glu 474 | conflict |
| Glu 492 | Gln 476 | conflict |
| Val 496 | Ile 480 | conflict |
| Arg 500 | Gly 484 | conflict |
| Cys 501 | Ala 485 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Val 504 | - | expression tag |
| Gly 505 | - | expression tag |
| Arg 506 | - | expression tag |
| Arg 507 | - | expression tag |
| Arg 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Arg 510 | - | expression tag |
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 355984.6 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 8798.1 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 3981.7 | |
| All* | Total formula weight | 368764.5 |
