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4LCF

Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex

Summary for 4LCF
Entry DOI10.2210/pdb4lcf/pdb
Related4LCG 4LCH
DescriptorUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, Nalpha-{4-[4-(4-aminophenyl)buta-1,3-diyn-1-yl]benzoyl}-N-hydroxy-L-histidinamide, ... (5 entities in total)
Functional Keywordslipid a biosynthesis, lipid a synthesis, baab sandwich, lpxc, deacetylation, acyl udp-glcnac, hydroxamate, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourcePseudomonas aeruginosa
Total number of polymer chains1
Total formula weight34438.33
Authors
Lee, C.-J.,Zhou, P. (deposition date: 2013-06-21, release date: 2013-08-21, Last modification date: 2024-02-28)
Primary citationLiang, X.,Lee, C.J.,Zhao, J.,Toone, E.J.,Zhou, P.
Synthesis, Structure, and Antibiotic Activity of Aryl-Substituted LpxC Inhibitors.
J.Med.Chem., 56:6954-6966, 2013
Cited by
PubMed: 23914798
DOI: 10.1021/jm4007774
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.599 Å)
Structure validation

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