5F59
| The crystal structure of MLL3 SET domain | 分子名称: | Histone-lysine N-methyltransferase 2C, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | 著者 | Li, Y, Lei, M, Chen, Y. | 登録日 | 2015-12-04 | 公開日 | 2016-02-24 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.801 Å) | 主引用文献 | Structural basis for activity regulation of MLL family methyltransferases. Nature, 530, 2016
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6BX3
| Structure of histone H3k4 methyltransferase | 分子名称: | COMPASS component BRE2, COMPASS component SDC1, COMPASS component SPP1, ... | 著者 | Skiniotis, G, Qu, Q.H. | 登録日 | 2017-12-16 | 公開日 | 2018-09-05 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex. Cell, 174, 2018
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6CF0
| Sperm Whale Myoglobin H64V Mutant with Nitrite | 分子名称: | GLYCEROL, Myoglobin, NITRITE ION, ... | 著者 | Powell, S.M, Wang, B, Thomas, L.M, Richter-Addo, G.B. | 登録日 | 2018-02-13 | 公開日 | 2018-05-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe -NO Ligand Orientations in Myoglobin Distal Pockets. Biochemistry, 57, 2018
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4PRJ
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4QCL
| Crystal structure of the catalytic core of human DNA polymerase alpha in ternary complex with an RNA-primed DNA template and dCTP | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA TEMPLATE, ... | 著者 | Baranovskiy, A.G, Suwa, Y, Babayeva, N.D, Gu, J, Tahirov, T.H. | 登録日 | 2014-05-12 | 公開日 | 2014-11-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Activity and fidelity of human DNA polymerase alpha depend on primer structure J.Biol.Chem., 2018
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3S36
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4PQN
| ITK kinase domain with compound GNE-9822 | 分子名称: | 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, Tyrosine-protein kinase ITK/TSK | 著者 | McEwan, P.A, Barker, J.J, Eigenbrot, C. | 登録日 | 2014-03-03 | 公開日 | 2014-07-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J.Med.Chem., 57, 2014
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3SGT
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3S35
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3SGV
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3S37
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3SGX
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3S34
| Structure of the 1121B Fab fragment | 分子名称: | 1121B Fab heavy chain, 1121B Fab light chain, PHOSPHATE ION | 著者 | Franklin, M.C. | 登録日 | 2011-05-17 | 公開日 | 2011-08-24 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies. Structure, 19, 2011
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3S29
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3SH0
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7XPZ
| Structure of Apo-hSLC19A1 | 分子名称: | Reduced folate transporter | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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7XQ0
| Structure of hSLC19A1+3'3'-CDA | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Reduced folate transporter | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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7XQ2
| Structure of hSLC19A1+2'3'-cGAMP | 分子名称: | Reduced folate transporter, cGAMP | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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7XQ1
| Structure of hSLC19A1+2'3'-CDAS | 分子名称: | (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, Reduced folate transporter | 著者 | Zhang, Q.X, Zhang, X.Y, Zhu, Y.L, Sun, P.P, Gao, A, Zhang, L.G, Gao, P. | 登録日 | 2022-05-06 | 公開日 | 2022-10-05 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Recognition of cyclic dinucleotides and folates by human SLC19A1. Nature, 612, 2022
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4MXK
| X-ray structure of Fe(II)-ZnPIXFeBMb1 | 分子名称: | FE (II) ION, Myoglobin, PROTOPORPHYRIN IX CONTAINING ZN | 著者 | Chakraborty, S, Lu, Y, Petrik, I. | 登録日 | 2013-09-26 | 公開日 | 2014-02-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Spectroscopic and computational study of a nonheme iron nitrosyl center in a biosynthetic model of nitric oxide reductase. Angew.Chem.Int.Ed.Engl., 53, 2014
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4IAN
| Crystal Structure of apo Human PRPF4B kinase domain | 分子名称: | SULFATE ION, Serine/threonine-protein kinase PRP4 homolog | 著者 | Mechin, I, Haas, K, Chen, X, Zhang, Y, McLean, L. | 登録日 | 2012-12-06 | 公開日 | 2013-08-28 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches. J.Biol.Chem., 288, 2013
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4R3R
| Crystal structures of EGFR in complex with Mig6 | 分子名称: | Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1' | 著者 | Park, E, Kim, N, Yi, Z, Cho, A, Kim, K, Ficarro, S.B, Park, A, Park, W.Y, Murray, B, Meyerson, M, Beroukim, R, Marto, J.A, Cho, J, Eck, M.J. | 登録日 | 2014-08-17 | 公開日 | 2015-08-12 | 最終更新日 | 2015-09-16 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat.Struct.Mol.Biol., 22, 2015
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4R5S
| Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3 | 分子名称: | Epidermal growth factor receptor, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | 著者 | Zhu, S.J, Yun, C.H. | 登録日 | 2014-08-22 | 公開日 | 2014-11-12 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | 主引用文献 | Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
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8JHF
| Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A.Z, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-15 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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8JHG
| Native SUV420H1 bound to 167-bp nucleosome | 分子名称: | DNA (160-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | 著者 | Lin, F, Li, W. | 登録日 | 2023-05-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis of nucleosomal H4K20 recognition and methylation by SUV420H1 methyltransferase. Cell Discov, 9, 2023
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