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4R5S

Crystal structure of EGFR 696-1022 L858R in complex with FIIN-3

Summary for 4R5S
Entry DOI10.2210/pdb4r5s/pdb
DescriptorEpidermal growth factor receptor, N-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide (3 entities in total)
Functional Keywordsegfr, l858r, kinase, fiin-3, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight38370.11
Authors
Zhu, S.J.,Yun, C.H. (deposition date: 2014-08-22, release date: 2014-11-12, Last modification date: 2022-08-24)
Primary citationTan, L.,Wang, J.,Tanizaki, J.,Huang, Z.,Aref, A.R.,Rusan, M.,Zhu, S.J.,Zhang, Y.,Ercan, D.,Liao, R.G.,Capelletti, M.,Zhou, W.,Hur, W.,Kim, N.,Sim, T.,Gaudet, S.,Barbie, D.A.,Yeh, J.R.,Yun, C.H.,Hammerman, P.S.,Mohammadi, M.,Janne, P.A.,Gray, N.S.
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc.Natl.Acad.Sci.USA, 111:E4869-E4877, 2014
Cited by
PubMed: 25349422
DOI: 10.1073/pnas.1403438111
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.001 Å)
Structure validation

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