4PRJ

Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)

Summary for 4PRJ

• Entry DOI: 10.2210/pdb4prj/pdb
• Descriptor: Aurora kinase A, N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide (2 entities in total)
• Functional Keywords: protein kinase, phospho-transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• Total number of polymer chains: 1
• Total formula weight: 31547.27

Authors

Ultsch, M.,Eigenbrot, C. (deposition date: 2014-03-05, release date: 2014-07-02, Last modification date: 2023-09-20)

• Primary citation: Burch, J.D.,Lau, K.,Barker, J.J.,Brookfield, F.,Chen, Y.,Chen, Y.,Eigenbrot, C.,Ellebrandt, C.,Ismaili, M.H.,Johnson, A.,Kordt, D.,MacKinnon, C.H.,McEwan, P.A.,Ortwine, D.F.,Stein, D.B.,Wang, X.,Winkler, D.,Yuen, P.W.,Zhang, Y.,Zarrin, A.A.,Pei, Z.; Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.; J.Med.Chem., 57:5714-5727, 2014; PubMed: 24918870; DOI: 10.1021/jm500550e

Experimental method

X-RAY DIFFRACTION (2.8 Å)