4PRJ
Aurora A kinase domain with compound 2 (N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 269 | 31138.9 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | A | N-[1-(3-cyanobenzyl)-1H-pyrazol-4-yl]-6-(1H-pyrazol-4-yl)-1H-indazole-3-carboxamide | non-polymer | 408.4 | 1 | Chemie (2VU) |
Sequence modifications
A: 124 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 123 | - | initiating methionine |
| Ala 124 | Lys 124 | engineered mutation |
| Asn 154 | Gln 154 | engineered mutation |
| Ser 203 | Ala 203 | engineered mutation |
| Lys 251 | Arg 251 | engineered mutation |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
| Asp 336 | Glu 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31138.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 408.4 | |
| All* | Total formula weight | 31547.3 |
