4PQN
ITK kinase domain with compound GNE-9822
Summary for 4PQN
Entry DOI | 10.2210/pdb4pqn/pdb |
Descriptor | Tyrosine-protein kinase ITK/TSK, N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... (4 entities in total) |
Functional Keywords | protein kinase, phospho-transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q08881 |
Total number of polymer chains | 1 |
Total formula weight | 30699.19 |
Authors | McEwan, P.A.,Barker, J.J.,Eigenbrot, C. (deposition date: 2014-03-03, release date: 2014-07-02, Last modification date: 2023-09-20) |
Primary citation | Burch, J.D.,Lau, K.,Barker, J.J.,Brookfield, F.,Chen, Y.,Chen, Y.,Eigenbrot, C.,Ellebrandt, C.,Ismaili, M.H.,Johnson, A.,Kordt, D.,MacKinnon, C.H.,McEwan, P.A.,Ortwine, D.F.,Stein, D.B.,Wang, X.,Winkler, D.,Yuen, P.W.,Zhang, Y.,Zarrin, A.A.,Pei, Z. Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J.Med.Chem., 57:5714-5727, 2014 Cited by PubMed: 24918870DOI: 10.1021/jm500550e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
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