Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4PQN

ITK kinase domain with compound GNE-9822

Summary for 4PQN
Entry DOI10.2210/pdb4pqn/pdb
DescriptorTyrosine-protein kinase ITK/TSK, N-{1-[(1S)-3-(dimethylamino)-1-phenylpropyl]-1H-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazole-3-carboxamide, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ... (4 entities in total)
Functional Keywordsprotein kinase, phospho-transfer, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: Q08881
Total number of polymer chains1
Total formula weight30699.19
Authors
McEwan, P.A.,Barker, J.J.,Eigenbrot, C. (deposition date: 2014-03-03, release date: 2014-07-02, Last modification date: 2023-09-20)
Primary citationBurch, J.D.,Lau, K.,Barker, J.J.,Brookfield, F.,Chen, Y.,Chen, Y.,Eigenbrot, C.,Ellebrandt, C.,Ismaili, M.H.,Johnson, A.,Kordt, D.,MacKinnon, C.H.,McEwan, P.A.,Ortwine, D.F.,Stein, D.B.,Wang, X.,Winkler, D.,Yuen, P.W.,Zhang, Y.,Zarrin, A.A.,Pei, Z.
Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors.
J.Med.Chem., 57:5714-5727, 2014
Cited by
PubMed: 24918870
DOI: 10.1021/jm500550e
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.71 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon