6CB6
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8AG1
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![BU of 8ag1 by Molmil](/molmil-images/mine/8ag1) | Crystal structure of a novel OX40 antibody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Novel OX40 antibody heavy chain, Novel OX40 antibody light chain, ... | 著者 | Gao, H, Zhou, A. | 登録日 | 2022-07-19 | 公開日 | 2023-07-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.303 Å) | 主引用文献 | Structural Basis of a Novel Agonistic Anti-OX40 Antibody. Biomolecules, 12, 2022
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8YLC
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![BU of 8ylc by Molmil](/molmil-images/mine/8ylc) | The crystal structure of PDE4D with Amentoflavone | 分子名称: | 3',5'-cyclic-AMP phosphodiesterase 4D, 8-[5-[5,7-bis(oxidanyl)-4-oxidanylidene-chromen-2-yl]-2-oxidanyl-phenyl]-2-(4-hydroxyphenyl)-5,7-bis(oxidanyl)chromen-4-one, MAGNESIUM ION, ... | 著者 | Huang, Y.-Y, Luo, H.-B. | 登録日 | 2024-03-06 | 公開日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (2.30003715 Å) | 主引用文献 | Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects Chin.Chem.Lett., 2024
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5Y27
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![BU of 5y27 by Molmil](/molmil-images/mine/5y27) | Crystal structure of Se-Met Dpb4-Dpb3 | 分子名称: | DNA polymerase epsilon subunit D, GLYCEROL, Putative transcription factor C16C4.22 | 著者 | Li, Y, Gao, F, Su, M, Zhang, F.B, Chen, Y.H. | 登録日 | 2017-07-24 | 公開日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6BR8
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![BU of 6br8 by Molmil](/molmil-images/mine/6br8) | Structure of A6 reveals a novel lipid transporter | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Deng, J, Peng, S, Pathak, P. | 登録日 | 2017-11-30 | 公開日 | 2018-06-20 | 最終更新日 | 2019-12-11 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6BR9
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![BU of 6br9 by Molmil](/molmil-images/mine/6br9) | Structure of A6 reveals a novel lipid transporter | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Deng, J, Peng, S, Pathak, P. | 登録日 | 2017-11-30 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7JRN
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![BU of 7jrn by Molmil](/molmil-images/mine/7jrn) | Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, SULFATE ION, ... | 著者 | Sacco, M, Ma, C, Wang, J, Chen, Y. | 登録日 | 2020-08-12 | 公開日 | 2020-08-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay. Acs Cent.Sci., 7, 2021
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4MI5
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![BU of 4mi5 by Molmil](/molmil-images/mine/4mi5) | Crystal structure of the EZH2 SET domain | 分子名称: | Histone-lysine N-methyltransferase EZH2, SULFATE ION, ZINC ION | 著者 | Antonysamy, S, Condon, B, Druzina, Z, Bonanno, J, Gheyi, T, Macewan, I, Zhang, A, Ashok, S, Russell, M, Luz, J.G. | 登録日 | 2013-08-30 | 公開日 | 2014-01-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain. Plos One, 8, 2013
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8WHA
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![BU of 8wha by Molmil](/molmil-images/mine/8wha) | Structure of DDM1-nucleosome complex in the ADP-BeFx state with DDM1 bound to SHL2 and SHL-2 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Liu, Y, Zhang, Z, Du, J. | 登録日 | 2023-09-22 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
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8WH9
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![BU of 8wh9 by Molmil](/molmil-images/mine/8wh9) | Structure of DDM1-nucleosome complex in ADP-BeFx state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Liu, Y, Zhang, Z, Du, J. | 登録日 | 2023-09-22 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
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8WH8
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![BU of 8wh8 by Molmil](/molmil-images/mine/8wh8) | Structure of DDM1-nucleosome complex in ADP state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent DNA helicase DDM1, DNA (antisense strand), ... | 著者 | Liu, Y, Zhang, Z, Du, J. | 登録日 | 2023-09-22 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
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8WHB
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![BU of 8whb by Molmil](/molmil-images/mine/8whb) | Structure of nucleosome core particle of Arabidopsis thaliana | 分子名称: | DNA (antisense strand), DNA (sense strand), Histone H2A.6, ... | 著者 | Liu, Y, Zhang, Z, Du, J. | 登録日 | 2023-09-23 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
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8WH5
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![BU of 8wh5 by Molmil](/molmil-images/mine/8wh5) | Structure of DDM1-nucleosome complex in the apo state | 分子名称: | ATP-dependent DNA helicase DDM1, DNA (antisense strand), DNA (sense strand), ... | 著者 | Liu, Y, Zhang, Z, Du, J. | 登録日 | 2023-09-22 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Molecular basis of chromatin remodelling by DDM1 involved in plant DNA methylation. Nat.Plants, 10, 2024
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7T9U
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![BU of 7t9u by Molmil](/molmil-images/mine/7t9u) | Crystal structure of hSTING with an agonist (SHR169224) | 分子名称: | (3S,4S)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4-(prop-2-en-1-yl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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7T9V
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![BU of 7t9v by Molmil](/molmil-images/mine/7t9v) | Crystal structure of hSTING with the agonist, SHR171032 | 分子名称: | (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, CALCIUM ION, Stimulator of interferon genes protein | 著者 | Chowdhury, R, Miller, M. | 登録日 | 2021-12-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12, 2022
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5ACY
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![BU of 5acy by Molmil](/molmil-images/mine/5acy) | N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1-(2R,4S)-2-methyl-4-(phenylamino)-6-4-(piperidin-1-ylmethyl)phenyl-1,2,3,4- tetrahydroquinolin-1-yl-ethan-1-one | 分子名称: | 1,2-ETHANEDIOL, 1-[(2S,4R)-2-methyl-4-(phenylamino)-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydroquinolin-1(2H)-yl]ethanone, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C. | 登録日 | 2015-08-18 | 公開日 | 2015-10-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Autism-Like Syndrome is Induced by Pharmacological Suppression of Bet Proteins in Young Mice. J.Exp.Med., 212, 2015
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5B2P
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![BU of 5b2p by Molmil](/molmil-images/mine/5b2p) | Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGA PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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5GPK
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![BU of 5gpk by Molmil](/molmil-images/mine/5gpk) | Crystal structure of Ccp1 mutant | 分子名称: | Putative nucleosome assembly protein C36B7.08c | 著者 | Yin, F, Gao, F, Chen, Y. | 登録日 | 2016-08-03 | 公開日 | 2016-11-30 | 実験手法 | X-RAY DIFFRACTION (2.103 Å) | 主引用文献 | Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading Mol.Cell, 64, 2016
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5GPL
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![BU of 5gpl by Molmil](/molmil-images/mine/5gpl) | Crystal structure of Ccp1 | 分子名称: | Putative nucleosome assembly protein C36B7.08c | 著者 | Yin, F, Gao, F, Chen, Y. | 登録日 | 2016-08-03 | 公開日 | 2016-11-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading Mol.Cell, 64, 2016
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5CZZ
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![BU of 5czz by Molmil](/molmil-images/mine/5czz) | Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGAAT PAM) | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2015-08-01 | 公開日 | 2015-09-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Staphylococcus aureus Cas9. Cell, 162, 2015
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4Y05
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![BU of 4y05 by Molmil](/molmil-images/mine/4y05) | KIF2C short Loop2 construct | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Kinesin-like protein KIF2C, MAGNESIUM ION, ... | 著者 | Wang, W, Knossow, M, Gigant, B. | 登録日 | 2015-02-05 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C. J.Biol.Chem., 290, 2015
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5B2Q
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![BU of 5b2q by Molmil](/molmil-images/mine/5b2q) | Crystal structure of Francisella novicida Cas9 RHA in complex with sgRNA and target DNA (TGG PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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5B43
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![BU of 5b43 by Molmil](/molmil-images/mine/5b43) | Crystal structure of Acidaminococcus sp. Cpf1 in complex with crRNA and target DNA | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cpf1, DNA (34-MER), ... | 著者 | Yamano, T, Nishimasu, H, Hirano, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-03-30 | 公開日 | 2016-05-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA Cell, 165, 2016
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5AXW
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![BU of 5axw by Molmil](/molmil-images/mine/5axw) | Crystal structure of Staphylococcus aureus Cas9 in complex with sgRNA and target DNA (TTGGGT PAM) | 分子名称: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, DNA (28-MER), ... | 著者 | Nishimasu, H, Ishitani, R, Nureki, O. | 登録日 | 2015-08-01 | 公開日 | 2015-09-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal Structure of Staphylococcus aureus Cas9. Cell, 162, 2015
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5B2O
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![BU of 5b2o by Molmil](/molmil-images/mine/5b2o) | Crystal structure of Francisella novicida Cas9 in complex with sgRNA and target DNA (TGG PAM) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Hirano, H, Nishimasu, H, Nakane, T, Ishitani, R, Nureki, O. | 登録日 | 2016-02-01 | 公開日 | 2016-03-02 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Engineering of Francisella novicida Cas9 Cell, 164, 2016
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