7JRN
Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617
Summary for 7JRN
Entry DOI | 10.2210/pdb7jrn/pdb |
Descriptor | Non-structural protein 3, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | covid, covid19, covid-19, sars, sars cov2, cov, ncov 19, coronavirus, main protease, 3cl, mpro, pro, viral protein, gc376, calpain inhibitor ii, leupeptin, calpain, aldehyde, gc-376, 3cl-like, a-ketoamide, alpheketoamide, alpha, ketoamide, peptidomimetic, protease, cysteine, hydrolase-hydrolase inhibitor complex, grl0617, papin-like protease, plp, plpro, pl-pro, papain |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 74705.19 |
Authors | |
Primary citation | Ma, C.,Sacco, M.D.,Xia, Z.,Lambrinidis, G.,Townsend, J.A.,Hu, Y.,Meng, X.,Szeto, T.,Ba, M.,Zhang, X.,Gongora, M.,Zhang, F.,Marty, M.T.,Xiang, Y.,Kolocouris, A.,Chen, Y.,Wang, J. Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay. Acs Cent.Sci., 7:1245-1260, 2021 Cited by PubMed: 34341772DOI: 10.1021/acscentsci.1c00519 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
Download full validation report