7JRN
Crystal structure of the wild type SARS-CoV-2 papain-like protease (PLPro) with inhibitor GRL0617
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, J) | Non-structural protein 3 | polymer | 323 | 36742.6 | 2 | UniProt (P0DTC1) Pfam (PF08715) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | nsp3,PL2-PRO,Papain-like protease,Papain-like proteinase,PL-PRO |
| 2 | C, G (A, J) | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide | non-polymer | 304.4 | 2 | Chemie (TTT) | |||
| 3 | D, H (A, J) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, I, J, K (A, J) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | L, M (A, J) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A, J: 1 - 315 (UniProt: P0DTC1)
| PDB | External Database | Details |
|---|---|---|
| Leu 316 | - | expression tag |
| Glu 317 | - | expression tag |
| His 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
| His 323 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73485.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1219.9 | |
| All* | Total formula weight | 74705.2 |
