5ACY

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1-(2R,4S)-2-methyl-4-(phenylamino)-6-4-(piperidin-1-ylmethyl)phenyl-1,2,3,4- tetrahydroquinolin-1-yl-ethan-1-one

Summary for 5ACY

Entry DOI	10.2210/pdb5acy/pdb
Descriptor	BROMODOMAIN-CONTAINING PROTEIN 4, 1,2-ETHANEDIOL, 1-[(2S,4R)-2-methyl-4-(phenylamino)-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydroquinolin-1(2H)-yl]ethanone, ... (4 entities in total)
Functional Keywords	transcription, inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus: O60885
Total number of polymer chains	2
Total formula weight	31292.20
Authors	Chung, C. (deposition date: 2015-08-18, release date: 2015-10-07, Last modification date: 2015-11-04)
Primary citation	Sullivan, J.M.,Badimon, A.,Schaefer, U.,Ayata, P.,Gray, J.,Chung, C.,Von Schimmelmann, M.,Zhang, F.,Garton, N.,Smithers, N.,Lewis, H.,Tarakhovsky, A.,Prinjha, R.K.,Schaefer, A. Autism-Like Syndrome is Induced by Pharmacological Suppression of Bet Proteins in Young Mice. J.Exp.Med., 212:1771-, 2015 Cited by PubMed: 26392221 DOI: 10.1084/JEM.20151271 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation