5ACY

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 1-(2R,4S)-2-methyl-4-(phenylamino)-6-4-(piperidin-1-ylmethyl)phenyl-1,2,3,4- tetrahydroquinolin-1-yl-ethan-1-one

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1169

Chain	Residue
A	ILE100
A	ILE101
A	LYS102
A	THR103
A	ASN135

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1170

Chain	Residue
B	ILE100
B	ILE138
A	THR50
A	SER51
A	ASN116
A	HOH2017

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1171

Chain	Residue
A	ARG113
A	ASP128

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site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 9S3 A 1172

Chain	Residue
A	TRP81
A	PRO82
A	GLN85
A	LEU92
A	CYS136
A	TYR139
A	ASN140
A	HOH2085
A	HOH2095
A	HOH2161
B	GLN78
B	TRP81
B	9S31169

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 9S3 B 1169

Chain	Residue
A	TRP81
A	9S31172
B	TRP81
B	PRO82
B	LEU92
B	LEU94
B	ASN140
B	HOH2080
B	HOH2142

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	212
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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