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CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
分子名称:	Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y.
登録日	2023-05-20
公開日	2024-01-10
実験手法	ELECTRON MICROSCOPY (2.84 Å)
主引用文献	Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023

6IHJ

Crystal structure of Drosophila Nxf1 NTF2 domain in complex with Nxt1/p15
分子名称:	NTF2-related export protein, Nuclear RNA export factor 1
著者	Huang, Y, Yuan, X.
登録日	2018-09-30
公開日	2019-08-14
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation. Nat.Cell Biol., 21, 2019

7W56

Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 1-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2024-10-23
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W57

Cryo-EM structure of the neuromedin S-bound neuromedin U receptor 2-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2022-06-15
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W55

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 2-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2022-06-15
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

7W53

Cryo-EM structure of the neuromedin U-bound neuromedin U receptor 1-Gq protein complex
分子名称:	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者	You, C, Xu, H.E, Jiang, Y.
登録日	2021-11-29
公開日	2022-04-20
最終更新日	2022-06-15
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun, 13, 2022

6IEW

The crystal structure of the dNxf2 UBA domain in complex with Panoramix
分子名称:	Fusion protein of Nuclear RNA export factor 2 and Protein panoramix, GLYCEROL
著者	Huang, Y, Cheng, S.
登録日	2018-09-17
公開日	2019-08-21
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation. Nat.Cell Biol., 21, 2019

6VAB

Mouse retromer sub-structure: VPS35/VPS35 flat dimer
分子名称:	Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
著者	Kendall, A.K, Jackson, L.P.
登録日	2019-12-17
公開日	2020-02-19
最終更新日	2024-03-06
実験手法	ELECTRON MICROSCOPY (4.9 Å)
主引用文献	Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes. Structure, 28, 2020

6VAC

Mouse retromer (VPS26/VPS35/VPS29) heterotrimer
分子名称:	Vacuolar protein sorting-associated protein 26A, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35
著者	Kendall, A.K, Jackson, L.P.
登録日	2019-12-17
公開日	2020-02-19
最終更新日	2024-03-06
実験手法	ELECTRON MICROSCOPY (5.7 Å)
主引用文献	Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes. Structure, 28, 2020

7VBH

Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex
分子名称:	Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-08-31
公開日	2022-04-06
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7D8T

MITF bHLHLZ complex with M-box DNA
分子名称:	DNA (5'-D(TPGPTPAPAPCPAPTPGPTPGPTPCPCPCPC)-3'), DNA (5'-D(PGPGPGPAPCPAPCPAPTPGPTPTPAPCPAPG)-3'), Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
著者	Guo, M, Fang, P, Wang, J.
登録日	2020-10-09
公開日	2021-10-13
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (3.201 Å)
主引用文献	A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023

7D8R

MITF HLHLZ structure
分子名称:	Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit
著者	Guo, M, Fang, P, Wang, J.
登録日	2020-10-09
公開日	2021-10-13
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023

7D8S

MITF bHLHLZ apo structure
分子名称:	Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION
著者	Guo, M, Fang, P, Wang, J.
登録日	2020-10-09
公開日	2021-10-13
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.28 Å)
主引用文献	A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023

7VAB

Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GIPR-Gs complex
分子名称:	CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者	Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-08-28
公開日	2022-03-02
最終更新日	2022-03-16
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7VBI

Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex
分子名称:	Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-08-31
公開日	2022-03-02
最終更新日	2022-03-16
実験手法	ELECTRON MICROSCOPY (3 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7FIN

Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GIPR-Gs complex
分子名称:	CHOLESTEROL, GAMMA-L-GLUTAMIC ACID, Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, ...
著者	Zhao, F.h, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-07-31
公開日	2022-02-23
最終更新日	2022-03-16
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7FIY

Cryo-EM structure of the tirzepatide-bound human GIPR-Gs complex
分子名称:	CHOLESTEROL, Gastric inhibitory polypeptide receptor,Gastric inhibitory polypeptide receptor,human glucose-dependent insulinotropic polypeptide receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者	Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-08-01
公開日	2022-03-02
最終更新日	2022-03-16
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7FIM

Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex
分子名称:	Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,Glucagon-like peptide 1 receptor,human glucagon like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者	Zhao, F.H, Zhou, Q.T, Cong, Z.T, Hang, K.N, Zou, X.Y, Zhang, C, Chen, Y, Dai, A.T, Liang, A.Y, Ming, Q.Q, Wang, M, Chen, L.N, Xu, P.Y, Chang, R.L, Feng, W.B, Xia, T, Zhang, Y, Wu, B.L, Yang, D.H, Zhao, L.H, Xu, H.E, Wang, M.W.
登録日	2021-07-31
公開日	2022-03-02
最終更新日	2022-03-16
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun, 13, 2022

7EOD

MITF HLHLZ Delta AKE
分子名称:	GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor
著者	Li, P, Liu, Z, Fang, P, Wang, J.
登録日	2021-04-22
公開日	2022-04-27
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023

4ZHM

The crystal structure of mupain-1--16-IG in complex with murinised human uPA at pH7.4
分子名称:	Urokinase-type plasminogen activator, mupain-1-16-IG, piperidine-1-carboximidamide
著者	Jiang, L, Andreasen, P.A, Huang, M.
登録日	2015-04-25
公開日	2015-09-16
最終更新日	2015-10-14
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol., 427, 2015

4ZHL

The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
分子名称:	Urokinase-type plasminogen activator, mupain-1-IG
著者	Jiang, L, Andreasen, P.A, Huang, M.
登録日	2015-04-25
公開日	2015-09-16
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (2.06 Å)
主引用文献	Selection of High-Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protease Fusions. J.Mol.Biol., 427, 2015

7E14

Compound2_GLP-1R_OWL833_Gs complex structure
分子名称:	3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, CHOLESTEROL, G protein, ...
著者	Cong, Z.T, Chen, L.N, Ma, H.L, Yang, D.H, Xu, H.E, Zhang, Y, Wang, M.W.
登録日	2021-01-30
公開日	2021-07-07
最終更新日	2024-03-27
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nat Commun, 12, 2021

7WQ4

Galanin-bound galanin receptor 2 in complex with Gq
分子名称:	CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ...
著者	Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日	2022-01-24
公開日	2022-04-20
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (2.6 Å)
主引用文献	Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022

7WQ3

Galanin-bound galanin receptor 1 in complex with Gi
分子名称:	CHOLESTEROL, Galanin, Galanin receptor type 1, ...
著者	Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y.
登録日	2022-01-24
公開日	2022-04-20
最終更新日	2022-10-19
実験手法	ELECTRON MICROSCOPY (2.7 Å)
主引用文献	Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022

1FVY

SOLUTION STRUCTURE OF THE OSTEOGENIC 1-31 FRAGMENT OF THE HUMAN PARATHYROID HORMONE
分子名称:	PARATHYROID HORMONE
著者	Chen, Z.
登録日	2000-09-20
公開日	2000-11-22
最終更新日	2024-05-29
実験手法	SOLUTION NMR
主引用文献	Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone. Biochemistry, 39, 2000

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表示件数:	25
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