7FIM

Cryo-EM structure of the tirzepatide (LY3298176)-bound human GLP-1R-Gs complex

Summary for 7FIM

• Entry DOI: 10.2210/pdb7fim/pdb
• EMDB information: 31603
• Descriptor: Nanobody-35, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• Functional Keywords: cryo-electron microscopy; g protein-coupled receptor; ligand recognition; receptor activation; unimolecular agonist, structural protein
• Biological source: synthetic construct; More
• Total number of polymer chains: 6
• Total formula weight: 180596.91

Authors

Zhao, F.H.,Zhou, Q.T.,Cong, Z.T.,Hang, K.N.,Zou, X.Y.,Zhang, C.,Chen, Y.,Dai, A.T.,Liang, A.Y.,Ming, Q.Q.,Wang, M.,Chen, L.N.,Xu, P.Y.,Chang, R.L.,Feng, W.B.,Xia, T.,Zhang, Y.,Wu, B.L.,Yang, D.H.,Zhao, L.H.,Xu, H.E.,Wang, M.W. (deposition date: 2021-07-31, release date: 2022-03-02, Last modification date: 2022-03-16)

• Primary citation: Zhao, F.,Zhou, Q.,Cong, Z.,Hang, K.,Zou, X.,Zhang, C.,Chen, Y.,Dai, A.,Liang, A.,Ming, Q.,Wang, M.,Chen, L.N.,Xu, P.,Chang, R.,Feng, W.,Xia, T.,Zhang, Y.,Wu, B.,Yang, D.,Zhao, L.,Xu, H.E.,Wang, M.W.; Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.; Nat Commun, 13:1057-1057, 2022; PubMed: 35217653; DOI: 10.1038/s41467-022-28683-0

Experimental method

ELECTRON MICROSCOPY (3.4 Å)