6OL2
 
 | | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | | 分子名称: | ACETATE ION, GLYCEROL, N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)ethyl]-2-iodobenzamide, ... | | 著者 | Chlebowicz, J, Akella, R, Sekulski, K, Humphreys, J.M, Durbacz, M.Z, He, H, Rodan, A, Posner, B, Goldsmith, E.J. | | 登録日 | 2019-04-15 | | 公開日 | 2020-04-15 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high throughput screening
To Be Published
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8TFV
 | | INSECT DEFENSE PEPTIDE | | 分子名称: | PROTEIN (THANATIN) | | 著者 | Mandard, N, Sodano, P, Labbe, H, Bonmatin, J.M, Bulet, P, Hetru, C, Ptak, M, Vovelle, F. | | 登録日 | 1998-11-24 | | 公開日 | 1998-12-02 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data.
Eur.J.Biochem., 256, 1998
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5UJK
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8V8Z
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6OD2
 | | Yeast Spc42 C-terminal Antiparallel Coiled-Coil | | 分子名称: | Spindle pole body component SPC42 | | 著者 | Drennan, A.C, Krishna, S, Seeger, M.A, Andreas, M.P, Gardner, J.M, Sether, E.K.R, Jaspersen, S.L, Rayment, I. | | 登録日 | 2019-03-25 | | 公開日 | 2019-04-24 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.435 Å) | | 主引用文献 | Structure and function of Spc42 coiled-coils in yeast centrosome assembly and duplication.
Mol.Biol.Cell, 30, 2019
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6ODI
 | | Structure of CagY from a cryo-EM reconstruction of a T4SS | | 分子名称: | Type IV secretion system apparatus protein CagY | | 著者 | Chung, J.M, Sheedlo, M.J, Campbell, A, Sawhney, N, Frick-Cheng, A.E, Lacy, D.B, Cover, T.L, Ohi, M.D. | | 登録日 | 2019-03-26 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure of the Helicobacter pylori Cag type IV secretion system.
Elife, 8, 2019
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8UH2
 | | Complex of C3b with the inhibitor albicin | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Albicin, Complement C3 beta chain, ... | | 著者 | Andersen, J.F, Lei, H, Strayer, E, Ribeiro, J.M. | | 登録日 | 2023-10-06 | | 公開日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | | 主引用文献 | The mechanism of a mosquito salivary inhibitor of the alternative C3 convertase is elucidated through structural analysis of its complex with C3bBb
To Be Published
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8V9B
 | | Lipoprotein(a) Kringle IV domain 7 - Lp(a) KIV7 in complex with LY3441732 | | 分子名称: | (2S,2'S)-3,3'-[carbonylbis(azanediyl-3,1-phenylene)]bis{2-[(3R)-pyrrolidin-1-ium-3-yl]propanoate}, Apolipoprotein(a), MAGNESIUM ION, ... | | 著者 | Hendle, J, Weichert, K, Sauder, J.M. | | 登録日 | 2023-12-07 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
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6P59
 | | Crystal structure of SIVrcm Vif-CBFbeta-ELOB-ELOC complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Core-binding factor subunit beta, Elongin-B, ... | | 著者 | Binning, J.M, Chesarino, N.M, Emerman, M, Gross, J.D. | | 登録日 | 2019-05-29 | | 公開日 | 2019-12-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.942214 Å) | | 主引用文献 | Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.
Cell Host Microbe, 26, 2019
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8URV
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3QBH
 | | Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors | | 分子名称: | (4S)-4-(2-hydroxy-5-{[(3S,4S,5R)-4-hydroxy-1,1-dioxido-5-{[3-(propan-2-yl)benzyl]amino}tetrahydro-2H-thiopyran-3-yl]methyl}benzyl)-3-propyl-1,3-oxazolidin-2-one, Beta-secretase 1 | | 著者 | Rondeau, J.M. | | 登録日 | 2011-01-13 | | 公開日 | 2011-03-23 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
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5XM3
 | | Crystal Structure of Methanol dehydrogenase from Methylophaga aminisulfidivorans | | 分子名称: | Glucose dehydrogenase, MAGNESIUM ION, Methanol dehydrogenase [cytochrome c] subunit 2, ... | | 著者 | Cao, T.P, Choi, J.M, Lee, S.H. | | 登録日 | 2017-05-12 | | 公開日 | 2018-03-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | | 主引用文献 | The crystal structure of methanol dehydrogenase, a quinoprotein from the marine methylotrophic bacterium Methylophaga aminisulfidivorans MPT
J. Microbiol., 56, 2018
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6PK4
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8SRX
 | | Crystal structure of BAK-BAX heterodimer with lysoPC | | 分子名称: | 1,2-ETHANEDIOL, Apoptosis regulator BAX, Bcl-2 homologous antagonist/killer, ... | | 著者 | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | | 登録日 | 2023-05-07 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
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8SRY
 | | Crystal structure of BAK-BAX heterodimer with C12E8 | | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, ... | | 著者 | Brouwer, J.M, Czabotar, P.E, Colman, P.M, Miller, M.S. | | 登録日 | 2023-05-08 | | 公開日 | 2023-12-27 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Febs J., 291, 2024
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6PGT
 | | Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state | | 分子名称: | GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION | | 著者 | Cui, D.S, Lipchock, J.M, Loria, J.P. | | 登録日 | 2019-06-24 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
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6PHA
 | | Protein Tyrosine Phosphatase 1B (1-301), F182A mutant, vanadate bound state | | 分子名称: | ACETATE ION, GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, ... | | 著者 | Cui, D.S, Lipchock, J.M, Loria, J.P. | | 登録日 | 2019-06-25 | | 公開日 | 2019-08-07 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | | 主引用文献 | Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B.
J.Am.Chem.Soc., 141, 2019
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6P7K
 | | Structure of HMG-CoA reductase from Burkholderia cenocepacia | | 分子名称: | 3-hydroxy-3-methylglutaryl coenzyme A reductase, ADENOSINE-5'-DIPHOSPHATE, COENZYME A | | 著者 | Walker, A.M, Peacock, R.B, Hicks, C.W, Dewing, S.M, Lewis, K.M, Abboud, J, Stewart, S.W.A, Kang, C, Watson, J.M. | | 登録日 | 2019-06-05 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.722 Å) | | 主引用文献 | Structural and Functional Characterization of Dynamic Oligomerization in Burkholderia cenocepacia HMG-CoA Reductase.
Biochemistry, 58, 2019
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5W89
 | | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-18 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-18 | | 著者 | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | | 登録日 | 2017-06-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5LO9
 | | Thiosulfate dehydrogenase (TsdBA) from Marichromatium purpuratum - "as isolated" form | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Cytochrome C, ... | | 著者 | Brito, J.A, Kurth, J.M, Reuter, J, Flegler, A, Koch, T, Franke, T, Klein, E, Rowe, S, Butt, J.N, Denkmann, K, Pereira, I.A.C, Dahl, C, Archer, M. | | 登録日 | 2016-08-08 | | 公開日 | 2016-10-12 | | 最終更新日 | 2017-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Electron Accepting Units of the Diheme Cytochrome c TsdA, a Bifunctional Thiosulfate Dehydrogenase/Tetrathionate Reductase.
J.Biol.Chem., 291, 2016
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5W90
 | | FEZ-1 metallo-beta-lactamase from Legionella gormanii modelled with unknown ligand | | 分子名称: | FEZ-1 protein, GLYCEROL, SULFATE ION, ... | | 著者 | Garcia-Saez, I, Mercuri, P.S, Kahn, R, Shabalin, I.G, Raczynska, J.E, Jaskolski, M, Minor, W, Papamicael, C, Frere, J.M, Galleni, M, Dideberg, O. | | 登録日 | 2017-06-22 | | 公開日 | 2018-06-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril.
J. Mol. Biol., 325, 2003
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5W8F
 | | Crystal structure of human Mcl-1 in complex with modified Bim BH3 peptide SAH-MS1-14 | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION, modified Bim BH3 peptide SAH-MS1-14 | | 著者 | Rezaei Araghi, R, Jenson, J.M, Grant, R.A, Keating, A.E. | | 登録日 | 2017-06-21 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5ULV
 | | Malate dehydrogenase from Methylobacterium extorquens | | 分子名称: | CALCIUM ION, Malate dehydrogenase | | 著者 | Gonzalez, J.M. | | 登録日 | 2017-01-25 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | | 主引用文献 | Conformational changes on substrate binding revealed by structures of Methylobacterium extorquens malate dehydrogenase.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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5UUP
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5V7K
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