6BM0
 
 | | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.8 A resolution | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | 著者 | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | | 登録日 | 2017-11-12 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
6BLY
 | | Cryo-EM structure of human CPSF-160-WDR33 complex at 3.36A resolution | | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | | 著者 | Sun, Y, Zhang, Y, Hamilton, K, Walz, T, Tong, L. | | 登録日 | 2017-11-12 | | 公開日 | 2017-11-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | | 主引用文献 | Molecular basis for the recognition of the human AAUAAA polyadenylation signal.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
5B5H
 | | Hydrophobic ice-binding site confer hyperactivity on antifreeze protein from a snow mold fungus | | 分子名称: | Antifreeze protein, SODIUM ION, SULFATE ION | | 著者 | Cheng, J, Hanada, Y, Miura, A, Tsuda, S, Kondo, H. | | 登録日 | 2016-05-06 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Hydrophobic ice-binding sites confer hyperactivity of an antifreeze protein from a snow mold fungus.
Biochem.J., 473, 2016
|
|
7FIJ
 | | luteinizing hormone/choriogonadotropin receptor | | 分子名称: | Lutropin-choriogonadotropic hormone receptor | | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | 登録日 | 2021-07-31 | | 公開日 | 2021-09-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
7FIH
 | | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs-Org43553 complex | | 分子名称: | 5-azanyl-N-tert-butyl-2-methylsulfanyl-4-[3-(2-morpholin-4-ylethanoylamino)phenyl]thieno[2,3-d]pyrimidine-6-carboxamide, Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, ... | | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | 登録日 | 2021-07-31 | | 公開日 | 2021-09-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
7FIG
 | | luteinizing hormone/choriogonadotropin receptor(S277I)-chorionic gonadotropin-Gs complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Camelid antibody VHH fragment Nb35, Choriogonadotropin subunit beta 3, ... | | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | 登録日 | 2021-07-31 | | 公開日 | 2021-09-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
7FII
 | | luteinizing hormone/choriogonadotropin receptor-chorionic gonadotropin-Gs complex | | 分子名称: | Choriogonadotropin subunit beta 3, Engineered Guanine nucleotide-binding protein G(s) subunit alpha, Glycoprotein hormones alpha chain, ... | | 著者 | Duan, J, Xu, P, Cheng, X, Mao, C, Croll, T, He, X, Shi, J, Luan, X, Yin, W, You, E, Liu, Q, Zhang, S, Jiang, H, Zhang, Y, Jiang, Y, Xu, H.E. | | 登録日 | 2021-07-31 | | 公開日 | 2021-09-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structures of full-length glycoprotein hormone receptor signalling complexes.
Nature, 598, 2021
|
|
1SPX
 | | Crystal Structure of Glucose Dehydrogenase of Caenorhabditis Elegans in the Apo-Form | | 分子名称: | short-chain reductase family member (5L265) | | 著者 | Schormann, N, Zhou, J, McCombs, D, Bray, T, Symersky, J, Huang, W.-Y, Luan, C.-H, Gray, R, Luo, D, Arabashi, A, Bunzel, B, Nagy, L, Lu, S, Li, S, Lin, G, Zhang, Y, Qiu, S, Tsao, J, Luo, M, Carson, M, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-03-17 | | 公開日 | 2004-03-23 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of Glucose Dehydrogenase of Caenorhabditis Elegans in the Apo-Form: A Member of the SDR-Family
To be Published
|
|
7DHS
 | | Crystal Structure Analysis of the BRD4 | | 分子名称: | 6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1R)-1-phenylethyl]benzo[cd]indol-2-one, Bromodomain-containing protein 4 | | 著者 | Wu, T, Xiang, Q, Wang, C, Wu, C, Zhang, C, Zhang, M, Liu, Z, Zhang, Y, Xiao, L, Xu, Y. | | 登録日 | 2020-11-17 | | 公開日 | 2021-09-15 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Y06014 is a selective BET inhibitor for the treatment of prostate cancer.
Acta Pharmacol.Sin., 42, 2021
|
|
4KDM
 | | Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin | | 著者 | Lu, X, Shi, Y, Zhang, W, Zhang, Y, Qi, J, Gao, G.F. | | 登録日 | 2013-04-25 | | 公開日 | 2013-07-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.496 Å) | | 主引用文献 | Structure and receptor-binding properties of an airborne transmissible avian influenza A virus hemagglutinin H5 (VN1203mut).
Protein Cell, 4, 2013
|
|
1P51
 | | Anabaena HU-DNA cocrystal structure (AHU6) | | 分子名称: | 5'-D(*GP*CP*AP*TP*AP*TP*CP*AP*AP*TP*TP*TP*GP*TP*TP*GP*CP*AP*T)-3', DNA-binding protein HU | | 著者 | Swinger, K.K, Lemberg, K.M, Zhang, Y, Rice, P.A. | | 登録日 | 2003-04-24 | | 公開日 | 2003-05-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Flexible DNA bending in HU-DNA cocrystal structures
Embo J., 22, 2003
|
|
7EVJ
 | | Crystal structure of CBP bromodomain liganded with 9c | | 分子名称: | 3-acetyl-1-((3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(hydroxymethyl)phenyl)carbamoyl)indolizin-7-yl dimethylcarbamate, CREB-binding protein, GLYCEROL, ... | | 著者 | Xiang, Q, Wang, C, Wu, T, Zhang, Y, Zhang, C, Luo, G, Wu, X, Shen, H, Xu, Y. | | 登録日 | 2021-05-21 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer.
J.Med.Chem., 65, 2022
|
|
3AAC
 | | Small heat shock protein hsp14.0 with the mutations of I120F and I122F in the form II crystal | | 分子名称: | Putative uncharacterized protein ST1653 | | 著者 | Takeda, K, Hayashi, T, Abe, T, Hirano, Y, Hanazono, Y, Yohda, M, Miki, K. | | 登録日 | 2009-11-13 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Dimer structure and conformational variability in the N-terminal region of an archaeal small heat shock protein, StHsp14.0
J.Struct.Biol., 174, 2011
|
|
1PFB
 | | Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27 | | 分子名称: | ACETIC ACID, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | | 著者 | Min, J.R, Zhang, Y, Xu, R.-M. | | 登録日 | 2003-05-24 | | 公開日 | 2003-10-07 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.
Genes Dev., 17, 2003
|
|
1T7S
 | | Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein | | 分子名称: | BAG-1 cochaperone | | 著者 | Symersky, J, Zhang, Y, Schormann, N, Li, S, Bunzel, R, Pruett, P, Luan, C.-H, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2004-05-10 | | 公開日 | 2004-05-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural genomics of Caenorhabditis elegans: structure of the BAG domain.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
3SMS
 | | Human Pantothenate kinase 3 in complex with a pantothenate analog | | 分子名称: | (2R)-N-[3-(heptylamino)-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide, ADENOSINE-5'-DIPHOSPHATE, Pantothenate kinase 3, ... | | 著者 | Mottaghi, K, Tempel, W, Hong, B, Smil, D, Bolshan, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2011-06-28 | | 公開日 | 2011-07-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Human Pantothenate kinase 3 in complex with a pantothenate analog
to be published
|
|
1SZP
 | | A Crystal Structure of the Rad51 Filament | | 分子名称: | DNA repair protein RAD51, SULFATE ION | | 著者 | Conway, A.B, Lynch, T.W, Zhang, Y, Fortin, G.S, Symington, L.S, Rice, P.A. | | 登録日 | 2004-04-06 | | 公開日 | 2004-07-13 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Crystal structure of a Rad51 filament.
Nat.Struct.Mol.Biol., 11, 2004
|
|
2M7F
 | |
3TN3
 | | Crystal structure of GkaP from Geobacillus kaustophilus HTA426 | | 分子名称: | COBALT (II) ION, Phosphotriesterase | | 著者 | An, J, Zhang, Z, Zhang, Y, Feng, Y, Wu, G. | | 登録日 | 2011-09-01 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides
to be published
|
|
4IMI
 | | Novel Modifications on C-terminal Domain of RNA Polymerase II can Fine- tune the Phosphatase Activity of Ssu72. | | 分子名称: | CG14216, CTD, PHOSPHATE ION, ... | | 著者 | Luo, Y, Yogesha, S.D, Zhang, Y. | | 登録日 | 2013-01-03 | | 公開日 | 2013-08-07 | | 最終更新日 | 2013-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Novel Modifications on C-terminal Domain of RNA Polymerase II Can Fine-tune the Phosphatase Activity of Ssu72.
Acs Chem.Biol., 8, 2013
|
|
3TN6
 | | Crystal structure of GkaP mutant R230H from Geobacillus kaustophilus HTA426 | | 分子名称: | COBALT (II) ION, Phosphotriesterase | | 著者 | An, J, Zhang, Z, Zhang, Y, Feng, Y, Wu, G. | | 登録日 | 2011-09-01 | | 公開日 | 2012-09-12 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Engineering a thermostable lactonase for enhanced phosphotriesterase activity against organophosphate pesticides
to be published
|
|
3TDB
 | | Human Pin1 bound to trans peptidomimetic inhibitor | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, N-[(1E,2R)-1-[(2R)-2-{[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}cyclopentylidene]-3-(phosphonooxy)propan-2-yl]-L-phenylalaninamide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | | 著者 | Zhang, M, Zhang, Y. | | 登録日 | 2011-08-10 | | 公開日 | 2012-06-27 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.267 Å) | | 主引用文献 | Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code.
Acs Chem.Biol., 7, 2012
|
|
7CG3
 | | Staggered ring conformation of CtHsp104 (Hsp104 from Chaetomium Thermophilum) | | 分子名称: | Heat shock protein 104 | | 著者 | Inoue, Y, Hanazono, Y, Noi, K, Kawamoto, A, Kimatsuka, M, Harada, R, Takeda, K, Iwamasa, N, Shibata, K, Noguchi, K, Shigeta, Y, Namba, K, Ogura, T, Miki, K, Shinohara, K, Yohda, M. | | 登録日 | 2020-06-30 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Split conformation of Chaetomium thermophilum Hsp104 disaggregase.
Structure, 29, 2021
|
|
7VLA
 | | Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex | | 分子名称: | C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... | | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
|
|
7VL8
 | | Cryo-EM structure of the Apo CCR1-Gi complex | | 分子名称: | C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | 登録日 | 2021-10-02 | | 公開日 | 2022-03-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
|
|
