7DHS
Crystal Structure Analysis of the BRD4
Summary for 7DHS
Entry DOI | 10.2210/pdb7dhs/pdb |
Descriptor | Bromodomain-containing protein 4, 6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1R)-1-phenylethyl]benzo[cd]indol-2-one (3 entities in total) |
Functional Keywords | brd4, bromodomain, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 34271.51 |
Authors | |
Primary citation | Wu, T.B.,Xiang, Q.P.,Wang, C.,Wu, C.,Zhang, C.,Zhang, M.F.,Liu, Z.X.,Zhang, Y.,Xiao, L.J.,Xu, Y. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. Acta Pharmacol.Sin., 42:2120-2131, 2021 Cited by PubMed: 33654218DOI: 10.1038/s41401-021-00614-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
Download full validation report