7DHS

Crystal Structure Analysis of the BRD4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Bromodomain-containing protein 4	polymer	141	16767.3	2	UniProt (O60885) Pfam (PF00439)	Homo sapiens (Human)	Protein HUNK1
2	C, D (A, B)	6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(1R)-1-phenylethyl]benzo[cd]indol-2-one	non-polymer		368.4	2	Chemie (H8C)
3	E, F (A, B)	water	water		18.0	62	Chemie (HOH)

Sequence modifications

A, B: 44 - 168 (UniProt: O60885)

PDB	External Database	Details
Met 28	-	expression tag
Lys 29	-	expression tag
Lys 30	-	expression tag
Gly 31	-	expression tag
His 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
Leu 38	-	expression tag
Val 39	-	expression tag
Pro 40	-	expression tag
Arg 41	-	expression tag
Gly 42	-	expression tag
Ser 43	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33534.7
Non-Polymers*	Number of molecules	2
	Total formula weight	736.9
All*	Total formula weight	34271.5

*Water molecules are not included.