3TDB

Human Pin1 bound to trans peptidomimetic inhibitor

Summary for 3TDB

• Entry DOI: 10.2210/pdb3tdb/pdb
• Related: 1F8A 1PIN 2ITK 2Q5A 3TCZ
• Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, N-[(1E,2R)-1-[(2R)-2-{[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl}cyclopentylidene]-3-(phosphonooxy)propan-2-yl]-L-phenylalaninamide, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (4 entities in total)
• Functional Keywords: ppiase domain, ww domain, peptidyl-prolyl isomerase, isomerase-inhibitor complex, isomerase/inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q13526
• Total number of polymer chains: 1
• Total formula weight: 18531.62

Authors

Zhang, M.,Zhang, Y. (deposition date: 2011-08-10, release date: 2012-06-27, Last modification date: 2024-02-28)

• Primary citation: Zhang, M.,Wang, X.J.,Chen, X.,Bowman, M.E.,Luo, Y.,Noel, J.P.,Ellington, A.D.,Etzkorn, F.A.,Zhang, Y.; Structural and Kinetic Analysis of Prolyl-isomerization/Phosphorylation Cross-Talk in the CTD Code.; Acs Chem.Biol., 7:1462-1470, 2012; PubMed: 22670809; DOI: 10.1021/cb3000887

Experimental method

X-RAY DIFFRACTION (2.267 Å)