5W5S
 
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5W6R
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5FV2
 | | Crystal structure of hVEGF in complex with VH domain antibody | | 分子名称: | VASCULAR ENDOTHELIAL GROWTH FACTOR, VH DOMAIN ANTIBODY | | 著者 | Chung, C, Batuwangala, T. | | 登録日 | 2016-02-02 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
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4R72
 | | Structure of the periplasmic binding protein AfuA from Actinobacillus pleuropneumoniae (apo form) | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ABC-type Fe3+ transport system, periplasmic component, ... | | 著者 | Sit, B, Calmettes, C, Moraes, T.F. | | 登録日 | 2014-08-26 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen.
Plos Pathog., 11, 2015
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5X94
 | | Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex | | 分子名称: | Cag pathogenicity island protein, Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Senda, M, Senda, T. | | 登録日 | 2017-03-05 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Cell Rep, 20, 2017
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5FV1
 | | Crystal structure of hVEGF in complex with VK domain antibody | | 分子名称: | VASCULAR ENDOTHELIAL GROWTH FACTOR A, VK DOMAIN ANTIBODY | | 著者 | Chung, C, Walker, A. | | 登録日 | 2016-02-02 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Novel Interaction Mechanism of a Domain Antibody Based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency Than Ranibizumab and Bevacizumab and Improved Capacity Over Aflibercept.
J.Biol.Chem., 291, 2016
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5X7B
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7LZD
 | | Crystal Structure of SETD2 bound to Compound 35 | | 分子名称: | 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETD2, ... | | 著者 | Farrow, N.A, Boriack-Sjodin, P. | | 登録日 | 2021-03-09 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
Acs Med.Chem.Lett., 12, 2021
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7LZB
 | | Crystal Structure of SETD2 bound to Compound 2 | | 分子名称: | BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD2, N-[(1r,4r)-4-(beta-alanylamino)cyclohexyl]-7-methyl-1H-indole-2-carboxamide, ... | | 著者 | Farrow, N.A, Boriack-Sjodin, P. | | 登録日 | 2021-03-09 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
Acs Med.Chem.Lett., 12, 2021
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7LZF
 | | Crystal Structure of SETD2 bound to Compound 57 | | 分子名称: | 1,2-ETHANEDIOL, 4-fluoro-N-[(1R,3S)-3-{(3S)-3-[(methanesulfonyl)(methyl)amino]pyrrolidin-1-yl}cyclohexyl]-7-methyl-1H-indole-2-carboxamide, Histone-lysine N-methyltransferase SETD2, ... | | 著者 | Farrow, N.A, Boriack-Sjodin, P. | | 登録日 | 2021-03-09 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.
Acs Med.Chem.Lett., 12, 2021
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6CNV
 | | INFLUENZA B/BRISBANE HEMAGGLUTININ FAB CR9115 SD84H COMPLEX | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR9114 Fab heavy chain, ... | | 著者 | Luo, J, Obmolova, G. | | 登録日 | 2018-03-09 | | 公開日 | 2018-11-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin.
Science, 362, 2018
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6CK8
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2PWO
 | | Crystal Structure of HIV-1 CA146 A92E Psuedo Cell | | 分子名称: | CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) | | 著者 | Kelly, B.N. | | 登録日 | 2007-05-11 | | 公開日 | 2007-09-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein.
J.Mol.Biol., 373, 2007
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2PWM
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6CNW
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2PXR
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3TOL
 | | Crystal structure of an engineered cytochrome cb562 that forms 1D, Zn-mediated coordination polymers | | 分子名称: | CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562, ... | | 著者 | Brodin, J.B, Tezcan, F.A. | | 登録日 | 2011-09-05 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays.
Nat Chem, 4, 2012
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6VJE
 | | Crystal structure of Pseudomonas aeruginosa penicillin-binding protein 3 (PBP3) complexed with ceftobiprole | | 分子名称: | (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, Peptidoglycan D,D-transpeptidase FtsI | | 著者 | van den Akker, F, Kumar, V. | | 登録日 | 2020-01-15 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3.
Antimicrob.Agents Chemother., 64, 2020
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3TOM
 | | Crystal structure of an engineered cytochrome cb562 that forms 2D, Zn-mediated sheets | | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562, ZINC ION | | 著者 | Brodin, J.B, Tezcan, F.A. | | 登録日 | 2011-09-05 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Metal-directed, chemically tunable assembly of one-, two- and three-dimensional crystalline protein arrays.
Nat Chem, 4, 2012
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5IL1
 | | Crystal structure of SAM-bound METTL3-METTL14 complex | | 分子名称: | 1,2-ETHANEDIOL, METTL14, METTL3, ... | | 著者 | Wang, X, Guan, Z, Zou, T, Yin, P. | | 登録日 | 2016-03-04 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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5IL0
 | | Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, METTL14, ... | | 著者 | Wang, X, Guan, Z, Zou, T, Yin, P. | | 登録日 | 2016-03-04 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.882 Å) | | 主引用文献 | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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5IL2
 | | Crystal structure of SAH-bound METTL3-METTL14 complex | | 分子名称: | 1,2-ETHANEDIOL, METTL14, METTL3, ... | | 著者 | Wang, X, Guan, Z, Zou, T, Yin, P. | | 登録日 | 2016-03-04 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.606 Å) | | 主引用文献 | Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
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7TY3
 | | Crystal Structure of SETD2 Bound to an Indole-based Inhibitor | | 分子名称: | 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETD2, N-[(1R,3R)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide, ... | | 著者 | Farrow, N.A. | | 登録日 | 2022-02-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Acs Med.Chem.Lett., 13, 2022
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7TY2
 | | Crystal Structure of SETD2 Bound to an Indole-based Inhibitor | | 分子名称: | Histone-lysine N-methyltransferase SETD2, N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide, S-ADENOSYLMETHIONINE, ... | | 著者 | Farrow, N.A. | | 登録日 | 2022-02-11 | | 公開日 | 2022-08-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.438 Å) | | 主引用文献 | Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies.
Acs Med.Chem.Lett., 13, 2022
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1FGI
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