7TY3
Crystal Structure of SETD2 Bound to an Indole-based Inhibitor
Summary for 7TY3
Entry DOI | 10.2210/pdb7ty3/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYLMETHIONINE, ... (6 entities in total) |
Functional Keywords | histone-lysine n-methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33012.71 |
Authors | Farrow, N.A. (deposition date: 2022-02-11, release date: 2022-08-31, Last modification date: 2024-04-03) |
Primary citation | Alford, J.S.,Lampe, J.W.,Brach, D.,Chesworth, R.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Kutok, J.L.,Raimondi, A.,Riera, T.V.,Shook, B.,Tang, C.,Totman, J.,Farrow, N.A. Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies. Acs Med.Chem.Lett., 13:1137-1143, 2022 Cited by PubMed: 35859865DOI: 10.1021/acsmedchemlett.2c00167 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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