7LZD

Crystal Structure of SETD2 bound to Compound 35

Summary for 7LZD

• Entry DOI: 10.2210/pdb7lzd/pdb
• Descriptor: Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYLMETHIONINE, ... (7 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33581.38

Authors

Farrow, N.A.,Boriack-Sjodin, P. (deposition date: 2021-03-09, release date: 2021-09-22, Last modification date: 2023-10-18)

• Primary citation: Lampe, J.W.,Alford, J.S.,Boriak-Sjodin, P.A.,Brach, D.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Foley, M.A.,Harvey, D.M.,Motwani, V.,Munchhof, M.J.,Raimondi, A.,Riera, T.V.,Tang, C.,Thomenius, M.J.,Totman, J.,Farrow, N.A.; Discovery of a First-in-Class Inhibitor of the Histone Methyltransferase SETD2 Suitable for Preclinical Studies.; Acs Med.Chem.Lett., 12:1539-1545, 2021; PubMed: 34671445; DOI: 10.1021/acsmedchemlett.1c00272

Experimental method

X-RAY DIFFRACTION (1.8 Å)