7TY2

Crystal Structure of SETD2 Bound to an Indole-based Inhibitor

Summary for 7TY2

Entry DOI	10.2210/pdb7ty2/pdb
Descriptor	Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYLMETHIONINE, ... (5 entities in total)
Functional Keywords	histone-lysine n-methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	32950.64
Authors	Farrow, N.A. (deposition date: 2022-02-11, release date: 2022-08-31, Last modification date: 2024-04-03)
Primary citation	Alford, J.S.,Lampe, J.W.,Brach, D.,Chesworth, R.,Cosmopoulos, K.,Duncan, K.W.,Eckley, S.T.,Kutok, J.L.,Raimondi, A.,Riera, T.V.,Shook, B.,Tang, C.,Totman, J.,Farrow, N.A. Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies. Acs Med.Chem.Lett., 13:1137-1143, 2022 Cited by PubMed: 35859865 DOI: 10.1021/acsmedchemlett.2c00167 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.438 Å)

Structure validation