3NAM
 
 | | SR Ca(2+)-ATPase in the HnE2 state complexed with the Thapsigargin derivative dOTg | | 分子名称: | (3S,3aR,4S,6S,6aS,8R,9R,9aR,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-2-oxododecahydroazuleno[4,5-b]furan-8-yl (2Z)-2-methylbut-2-enoate, MAGNESIUM ION, PHOSPHATIDYLETHANOLAMINE, ... | | 著者 | Winther, A.M.L, Sonntag, Y, Olesen, C, Moller, J.V, Nissen, P. | | 登録日 | 2010-06-02 | | 公開日 | 2010-06-30 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Critical roles of hydrophobicity and orientation of side chains for inactivation of sarcoplasmic reticulum Ca2+-ATPase with thapsigargin and thapsigargin analogs
J.Biol.Chem., 285, 2010
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1QBM
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4I3L
 | | Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one | | 分子名称: | 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. | | 登録日 | 2012-11-26 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.292 Å) | | 主引用文献 | Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett, 4, 2013
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4I3K
 | | Crystal structure of a metabolic reductase with 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one | | 分子名称: | 1-hydroxy-6-(4-hydroxybenzyl)-4-methylpyridin-2(1H)-one, Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Zheng, B, Yao, Y, Liu, Z, Deng, L, Anglin, J.L, Jiang, H, Prasad, B.V.V, Song, Y. | | 登録日 | 2012-11-26 | | 公開日 | 2013-05-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.3056 Å) | | 主引用文献 | Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett, 4, 2013
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3RAS
 | | Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) complexed with a lipophilic phosphonate inhibitor | | 分子名称: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... | | 著者 | Diao, J, Deng, L, Prasad, B.V.V, Song, Y. | | 登録日 | 2011-03-28 | | 公開日 | 2011-05-25 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
J.Med.Chem., 54, 2011
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1Q5K
 | | crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor | | 分子名称: | Glycogen synthase kinase-3 beta, N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA | | 著者 | Bhat, R, Xue, Y, Berg, S, Hellberg, S, Ormo, M, Nilsson, Y, Radesater, A.C, Jerning, E, Markgren, P.O, Borgegard, T, Nylof, M, Gimenez-Cassina, A, Hernandez, F, Lucas, J.J, Diaz-Mido, J, Avila, J. | | 登録日 | 2003-08-08 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
J.Biol.Chem., 278, 2003
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3SR4
 | | Crystal Structure of Human DOT1L in Complex with a Selective Inhibitor | | 分子名称: | (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ACETATE ION, GLYCEROL, ... | | 著者 | Diao, J, Chen, P, Yao, Y, Prasad, B.V.V, Song, Y. | | 登録日 | 2011-07-06 | | 公開日 | 2011-10-05 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.
J.Am.Chem.Soc., 133, 2011
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1WEJ
 | | IGG1 FAB FRAGMENT (OF E8 ANTIBODY) COMPLEXED WITH HORSE CYTOCHROME C AT 1.8 A RESOLUTION | | 分子名称: | CYTOCHROME C, E8 ANTIBODY, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Mylvaganam, S.E, Paterson, Y, Getzoff, E.D. | | 登録日 | 1998-03-26 | | 公開日 | 1998-12-09 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for the binding of an anti-cytochrome c antibody to its antigen: crystal structures of FabE8-cytochrome c complex to 1.8 A resolution and FabE8 to 2.26 A resolution.
J.Mol.Biol., 281, 1998
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7ME0
 | | Cryo-EM structure of SARS-CoV-2 NSP15 NendoU at pH 6.0 | | 分子名称: | Uridylate-specific endoribonuclease | | 著者 | Godoy, A.S, Song, Y, Nakamura, A.M, Noske, G.D, Gawriljuk, V.O, Fernandes, R.S, Oliva, G. | | 登録日 | 2021-04-06 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (2.48 Å) | | 主引用文献 | Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.
Nucleic Acids Res., 2023
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4GAE
 | | Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, ... | | 著者 | Diao, J, Xue, J, Cai, G, Deng, L, Song, Y. | | 登録日 | 2012-07-25 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase.
ACS Med Chem Lett, 4, 2013
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4IN1
 | | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | | 分子名称: | 3C-like protease, SULFATE ION | | 著者 | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | | 登録日 | 2013-01-03 | | 公開日 | 2013-02-20 | | 最終更新日 | 2020-01-29 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
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4IMQ
 | | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | | 分子名称: | 3C-like protease, PEPTIDE INHIBITOR, syc8, ... | | 著者 | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | | 登録日 | 2013-01-03 | | 公開日 | 2013-02-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
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4IN2
 | | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | | 分子名称: | C-like protease | | 著者 | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | | 登録日 | 2013-01-03 | | 公開日 | 2013-02-20 | | 最終更新日 | 2013-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
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4INH
 | | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | | 分子名称: | DIMETHYL SULFOXIDE, Genome polyprotein, peptide inhibitor, ... | | 著者 | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | | 登録日 | 2013-01-04 | | 公開日 | 2013-02-20 | | 最終更新日 | 2013-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
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4IMZ
 | | Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus | | 分子名称: | Genome polyprotein, SODIUM ION, THIOCYANATE ION, ... | | 著者 | Prasad, B.V.V, Muhaxhiri, Z, Deng, L, Shanker, S, Sankaran, B, Estes, M.K, Palzkill, T, Song, Y. | | 登録日 | 2013-01-03 | | 公開日 | 2013-02-20 | | 最終更新日 | 2013-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis of substrate specificity and protease inhibition in norwalk virus.
J.Virol., 87, 2013
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3US9
 | | Crystal Structure of the NCX1 Intracellular Tandem Calcium Binding Domains(CBD12) | | 分子名称: | CALCIUM ION, Sodium/calcium exchanger 1 | | 著者 | Giladi, M, Sasson, Y, Hirsch, J.A, Khananshvili, D. | | 登録日 | 2011-11-23 | | 公開日 | 2012-07-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
Plos One, 7, 2012
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2C4J
 | | Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate | | 分子名称: | GLUTATHIONE S-TRANSFERASE MU 2, L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE | | 著者 | Tars, K, Andersson, M, Ivarsson, Y, Olin, B, Mannervik, B. | | 登録日 | 2005-10-20 | | 公開日 | 2005-10-26 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution.
Proc.Natl.Acad.Sci.USA, 103, 2006
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2IZ3
 | | Solution structure of human beta-microseminoprotein | | 分子名称: | BETA-MICROSEMINOPROTEIN | | 著者 | Ghasriani, H, Teilum, K, Johnsson, Y, Fernlund, P, Drakenberg, T. | | 登録日 | 2006-07-24 | | 公開日 | 2006-10-24 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Human and Porcine Beta-Microseminoprotein
J.Mol.Biol., 362, 2006
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2JCS
 | | Active site mutant of dNK from D. melanogaster with dTTP bound | | 分子名称: | DEOXYNUCLEOSIDE KINASE, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE | | 著者 | Egeblad-Welin, L, Sonntag, Y, Eklund, H, Munch-Petersen, B. | | 登録日 | 2007-01-03 | | 公開日 | 2007-02-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Functional Studies of Active-Site Mutants from Drosophila Melanogaster Deoxyribonucleoside Kinase. Investigations of the Putative Catalytic Glutamate- Arginine Pair and of Residues Responsible for Substrate Specificity.
FEBS J., 274, 2007
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2IZ4
 | | Solution structure of porcine beta-microseminoprotein | | 分子名称: | BETA-MICROSEMINOPROTEIN | | 著者 | Ghasriani, H, Teilum, K, Johnsson, Y, Fernlund, P, Drakenberg, T. | | 登録日 | 2006-07-24 | | 公開日 | 2006-10-24 | | 最終更新日 | 2020-01-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of Human and Porcine Beta-Microseminoprotein
J.Mol.Biol., 362, 2006
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2LP1
 | | The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99) | | 分子名称: | C99 | | 著者 | Barrett, P.J, Song, Y, Van Horn, W.D, Hustedt, E.J, Schafer, J.M, Hadziselimovic, A, Beel, A.J, Sanders, C.R. | | 登録日 | 2012-01-30 | | 公開日 | 2012-06-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.
Science, 336, 2012
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2MV0
 | | Solution NMR Structure of Maltose-binding protein from Escherichia coli, Northeast Structural Genomics Consortium (NESG) Target ER690 | | 分子名称: | Maltose-binding periplasmic protein | | 著者 | Rossi, P, Lange, O.F, Sgourakis, N.G, Song, Y, Lee, H, Aramini, J.M, Ertekin, A, Xiao, R, Acton, T.B, Baker, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2014-09-18 | | 公開日 | 2014-12-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2NDJ
 | | Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel | | 分子名称: | Potassium voltage-gated channel subfamily E member 3 | | 著者 | Sanders, C.R, Van Horn, W.D, Kroncke, B.M, Sisco, N.J, Meiler, J, Vanoye, C.G, Song, Y, Nannemann, D.P, Welch, R.C, Kang, C, Smith, J, George, A.L. | | 登録日 | 2016-06-09 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2, 2016
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7CSW
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7CSV
 | | Pseudomonas aeruginosa antitoxin HigA | | 分子名称: | HTH cro/C1-type domain-containing protein | | 著者 | Song, Y.J, Luo, G.H, Bao, R. | | 登録日 | 2020-08-17 | | 公開日 | 2021-01-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Pseudomonas aeruginosa antitoxin HigA functions as a diverse regulatory factor by recognizing specific pseudopalindromic DNA motifs.
Environ.Microbiol., 23, 2021
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