4IN2

Structural Basis of Substrate Specificity and Protease Inhibition in Norwalk Virus

Summary for 4IN2

• Entry DOI: 10.2210/pdb4in2/pdb
• Related: 4IMQ 4IMZ
• Descriptor: C-like protease (2 entities in total)
• Functional Keywords: protease, hydrolase
• Biological source: Norovirus (Hu/NV/NV/1968/US)
• Cellular location: Protein p48: Host membrane; Single-pass membrane protein (Potential). NTPase: Host membrane; Single-pass membrane protein (Potential). Protein p22: Host membrane; Single-pass membrane protein (Potential): Q83883
• Total number of polymer chains: 2
• Total formula weight: 39153.07

Authors

Prasad, B.V.V.,Muhaxhiri, Z.,Deng, L.,Shanker, S.,Sankaran, B.,Estes, M.K.,Palzkill, T.,Song, Y. (deposition date: 2013-01-03, release date: 2013-02-20, Last modification date: 2013-04-10)

• Primary citation: Muhaxhiri, Z.,Deng, L.,Shanker, S.,Sankaran, B.,Estes, M.K.,Palzkill, T.,Song, Y.,Prasad, B.V.; Structural basis of substrate specificity and protease inhibition in norwalk virus.; J.Virol., 87:4281-4292, 2013; PubMed: 23365454; DOI: 10.1128/JVI.02869-12

Experimental method

X-RAY DIFFRACTION (2.401 Å)