4GAE
Crystal structure of plasmodium dxr in complex with a pyridine-containing inhibitor
Summary for 4GAE
Entry DOI | 10.2210/pdb4gae/pdb |
Related | 3AU9 |
Descriptor | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [(1R)-3-[acetyl(hydroxy)amino]-1-(pyridin-4-yl)propyl]phosphonic acid, ... (9 entities in total) |
Functional Keywords | nadph binding, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Plasmodium falciparum |
Cellular location | Plastid, apicoplast: O96693 |
Total number of polymer chains | 2 |
Total formula weight | 100224.87 |
Authors | |
Primary citation | Xue, J.,Diao, J.,Cai, G.,Deng, L.,Zheng, B.,Yao, Y.,Song, Y. Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. ACS Med Chem Lett, 4:278-282, 2013 Cited by PubMed: 23795240DOI: 10.1021/ml300419r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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