4I3L
Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
Summary for 4I3L
Entry DOI | 10.2210/pdb4i3l/pdb |
Related | 3MAP |
Descriptor | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | isocitrate dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O75874 |
Total number of polymer chains | 2 |
Total formula weight | 95300.57 |
Authors | Zheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.V.,Song, Y. (deposition date: 2012-11-26, release date: 2013-05-22, Last modification date: 2024-02-28) |
Primary citation | Zheng, B.,Yao, Y.,Liu, Z.,Deng, L.,Anglin, J.L.,Jiang, H.,Prasad, B.V.,Song, Y. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett, 4:542-546, 2013 Cited by PubMed: 23795241DOI: 10.1021/ml400036z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.292 Å) |
Structure validation
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