3MAP

Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate

Summary for 3MAP

• Entry DOI: 10.2210/pdb3map/pdb
• Related: 3MAR 3MAS
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID (3 entities in total)
• Functional Keywords: isocitrate dehydrogenase, nicotinamide adenine dinucleotide phosphate, rossmann fold, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : O75874
• Total number of polymer chains: 2
• Total formula weight: 97415.69

Authors

Yang, B.,Peng, Y.,Ding, J. (deposition date: 2010-03-24, release date: 2010-11-10, Last modification date: 2023-11-01)

• Primary citation: Yang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J.; Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.; Cell Res., 20:1188-1200, 2010; PubMed: 20975740; DOI: 10.1038/cr.2010.145

Experimental method

X-RAY DIFFRACTION (2.8 Å)