2C4J

Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate

Summary for 2C4J

Entry DOI	10.2210/pdb2c4j/pdb
Related	1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2GTU 3GTU
Descriptor	GLUTATHIONE S-TRANSFERASE MU 2, L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE (3 entities in total)
Functional Keywords	glutathione, glutathione transferase, transferase, m2-2, multigene family
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	104760.40
Authors	Tars, K.,Andersson, M.,Ivarsson, Y.,Olin, B.,Mannervik, B. (deposition date: 2005-10-20, release date: 2005-10-26, Last modification date: 2023-12-13)
Primary citation	Norrgard, M.A.,Ivarsson, Y.,Tars, K.,Mannervik, B. Alternative Mutations of a Positively Selected Residue Elicit Gain or Loss of Functionalities in Enzyme Evolution. Proc.Natl.Acad.Sci.USA, 103:4876-, 2006 Cited by PubMed: 16549767 DOI: 10.1073/PNAS.0600849103 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation