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2C4J

Human glutathione-S-transferase M2-2 T210S mutant in complex with glutathione-styrene oxide conjugate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005102molecular_functionsignaling receptor binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016529cellular_componentsarcoplasmic reticulum
A0016740molecular_functiontransferase activity
A0018916biological_processnitrobenzene metabolic process
A0019899molecular_functionenzyme binding
A0042178biological_processxenobiotic catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043295molecular_functionglutathione binding
A0043651biological_processlinoleic acid metabolic process
A0045171cellular_componentintercellular bridge
A0051122biological_processhepoxilin biosynthetic process
A0055119biological_processrelaxation of cardiac muscle
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0070458biological_processcellular detoxification of nitrogen compound
A0071313biological_processcellular response to caffeine
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005102molecular_functionsignaling receptor binding
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006749biological_processglutathione metabolic process
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016529cellular_componentsarcoplasmic reticulum
B0016740molecular_functiontransferase activity
B0018916biological_processnitrobenzene metabolic process
B0019899molecular_functionenzyme binding
B0042178biological_processxenobiotic catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043295molecular_functionglutathione binding
B0043651biological_processlinoleic acid metabolic process
B0045171cellular_componentintercellular bridge
B0051122biological_processhepoxilin biosynthetic process
B0055119biological_processrelaxation of cardiac muscle
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0070062cellular_componentextracellular exosome
B0070458biological_processcellular detoxification of nitrogen compound
B0071313biological_processcellular response to caffeine
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005102molecular_functionsignaling receptor binding
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016529cellular_componentsarcoplasmic reticulum
C0016740molecular_functiontransferase activity
C0018916biological_processnitrobenzene metabolic process
C0019899molecular_functionenzyme binding
C0042178biological_processxenobiotic catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043295molecular_functionglutathione binding
C0043651biological_processlinoleic acid metabolic process
C0045171cellular_componentintercellular bridge
C0051122biological_processhepoxilin biosynthetic process
C0055119biological_processrelaxation of cardiac muscle
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0070458biological_processcellular detoxification of nitrogen compound
C0071313biological_processcellular response to caffeine
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0004602molecular_functionglutathione peroxidase activity
D0005102molecular_functionsignaling receptor binding
D0005504molecular_functionfatty acid binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006749biological_processglutathione metabolic process
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016529cellular_componentsarcoplasmic reticulum
D0016740molecular_functiontransferase activity
D0018916biological_processnitrobenzene metabolic process
D0019899molecular_functionenzyme binding
D0042178biological_processxenobiotic catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043295molecular_functionglutathione binding
D0043651biological_processlinoleic acid metabolic process
D0045171cellular_componentintercellular bridge
D0051122biological_processhepoxilin biosynthetic process
D0055119biological_processrelaxation of cardiac muscle
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0070062cellular_componentextracellular exosome
D0070458biological_processcellular detoxification of nitrogen compound
D0071313biological_processcellular response to caffeine
D0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GSO A1219
ChainResidue
ATYR7
AGLN72
ASER73
ATYR116
ASER210
AHOH2079
AHOH2095
AHOH2227
AHOH2228
AHOH2229
AHOH2230
ATRP8
BASP106
ALEU13
AMET35
AARG43
ATRP46
ALYS50
AASN59
ALEU60

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GSO B1219
ChainResidue
AASP106
BTYR7
BTRP8
BLEU13
BARG43
BTRP46
BLYS50
BASN59
BLEU60
BPRO61
BGLN72
BSER73
BSER210
BHOH2124
BHOH2149
BHOH2309
BHOH2310
BHOH2311
BHOH2312

site_idAC3
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GSO C1219
ChainResidue
CTYR7
CTRP8
CLEU13
CMET35
CARG43
CTRP46
CLYS50
CASN59
CLEU60
CPRO61
CGLN72
CSER73
CTYR116
CSER210
CHOH2033
CHOH2051
CHOH2053
CHOH2145
DASP106

site_idAC4
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GSO D1219
ChainResidue
CASP106
DTYR7
DTRP8
DLEU13
DMET35
DTRP46
DLYS50
DASN59
DLEU60
DPRO61
DGLN72
DSER73
DTYR116
DSER210
DHOH2089
DHOH2092
DHOH2112
DHOH2273
DHOH2274
DHOH2275

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:19808963
ChainResidueDetails
ATRP8
CSER44
CLEU60
CSER73
DTRP8
DSER44
DLEU60
DSER73
ASER44
ALEU60
ASER73
BTRP8
BSER44
BLEU60
BSER73
CTRP8

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P08010
ChainResidueDetails
APHE51
BPHE51
CPHE51
DPHE51

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP117
BASP117
CASP117
DASP117

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Important for substrate specificity
ChainResidueDetails
ALYS211
BLYS211
CLYS211
DLYS211

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08010
ChainResidueDetails
ATYR28
AGLN45
BTYR28
BGLN45
CTYR28
CGLN45
DTYR28
DGLN45

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR7

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR7

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
CTYR7

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
DTYR7

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PDB entries from 2024-07-17

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