5H6M
| DNA targeting ADP-ribosyltransferase Pierisin-1 | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
5H6J
| DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | 登録日 | 2016-11-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1 J. Biol. Chem., 292, 2017
|
|
5GIE
| Crystal structure of VDR in complex with DLAM-4P (P21 form) | 分子名称: | (3R,5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-7a-methyl-4-[(2Z)-2-[(3S,5R)-2-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methyl-3-oxidanyl-1-(4-phenylbutyl)pyrrolidin-2-one, SRC1, Vitamin D3 receptor | 著者 | Asano, L, Shimizu, T. | 登録日 | 2016-06-23 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.387 Å) | 主引用文献 | Regulation of the vitamin D receptor by vitamin D lactam derivatives. Febs Lett., 590, 2016
|
|
5GID
| Crystal structure of VDR in complex with DLAM-4 (C2 form) | 分子名称: | (3R,5S)-5-[(2R)-2-[(1R,3aS,4E,7aR)-7a-methyl-4-[(2Z)-2-[(3S,5R)-2-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]propyl]-3-methyl-3-oxidanyl-1-(4-phenylbutyl)pyrrolidin-2-one, SRC1, Vitamin D3 receptor | 著者 | Asano, L, Shimizu, T. | 登録日 | 2016-06-23 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | 主引用文献 | Regulation of the vitamin D receptor by vitamin D lactam derivatives. Febs Lett., 590, 2016
|
|
5HDH
| Crystal structure of human TLR8 with an uncleaved Z-loop | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2016-01-05 | 公開日 | 2016-03-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8 Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
5Z14
| Crystal structure of human TLR8 in complex with CU-CPT9a | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2017-12-25 | 公開日 | 2018-07-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State To Be Published
|
|
7C77
| Cryo-EM structure of mouse TLR3 in complex with UNC93B1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2020-05-23 | 公開日 | 2021-01-06 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nat.Struct.Mol.Biol., 28, 2021
|
|
7C76
| Cryo-EM structure of human TLR3 in complex with UNC93B1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2020-05-23 | 公開日 | 2021-01-06 | 最終更新日 | 2021-02-24 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nat.Struct.Mol.Biol., 28, 2021
|
|
8J6N
| Crystal structure of Cystathionine gamma-lyase in complex with compound 1 | 分子名称: | 1,2-ETHANEDIOL, Cystathionine gamma-lyase, GLYCEROL, ... | 著者 | Hibi, R, Toma-Fukai, S, Shimizu, T, Hanaoka, K. | 登録日 | 2023-04-26 | 公開日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a cystathionine gamma-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5'-phosphate (PLP) via Schiff base formation. Sci Rep, 13, 2023
|
|
7CRF
| Crystal structure of human TLR8 in complex with CU-CPD107 | 分子名称: | 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | 著者 | Sakaniwa, K, Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2020-08-13 | 公開日 | 2021-06-23 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun, 12, 2021
|
|
7CYN
| Cryo-EM structure of human TLR7 in complex with UNC93B1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein unc-93 homolog B1, ... | 著者 | Ohto, U, Ishida, H, Shimizu, T. | 登録日 | 2020-09-03 | 公開日 | 2021-01-06 | 最終更新日 | 2021-02-24 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structures of Toll-like receptors in complex with UNC93B1. Nat.Struct.Mol.Biol., 28, 2021
|
|
8K7T
| Mouse Fc epsilon RI in complex with mIgE Fc | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | 著者 | Zhang, Z, Yui, M, Ohto, U, Shimizu, T. | 登録日 | 2023-07-27 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Mouse Fc epsilon RI in complex withMouse Fc epsilon RI in complex with mIgE Fc mIgE Fc To Be Published
|
|
8HRX
| Cryo-EM structure of human NTCP-myr-preS1-YN9048Fab complex | 分子名称: | Fab heavy chain from antibody IgG clone number YN9048, Fab light chain from antibody IgG clone number YN9048, PreS1 protein (Fragment), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2022-12-16 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural basis of hepatitis B virus receptor binding. Nat.Struct.Mol.Biol., 31, 2024
|
|
8HRY
| Cryo-EM structure of human NTCP-myr-preS1-YN9016Fab complex | 分子名称: | Fab heavy chain from antibody IgG clone number YN9016, Fab light chain from antibody IgG clone number YN9016, Large S protein (Fragment), ... | 著者 | Asami, J, Shimizu, T, Ohto, U. | 登録日 | 2022-12-16 | 公開日 | 2024-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis of hepatitis B virus receptor binding. Nat.Struct.Mol.Biol., 31, 2024
|
|
6KYA
| Crystal structure of human TLR8 in complex TH1027 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | 著者 | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | 登録日 | 2019-09-17 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J.Med.Chem., 63, 2020
|
|
7VGR
| |
7VGS
| |
5AWB
| Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | 分子名称: | 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2015-09-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
|
|
5AWC
| Crystal structure of human TLR8 in complex with MB-564 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2016-07-20 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
|
|
5AZ5
| Crystal structure of human TLR8 in complex with MB-343 | 分子名称: | 1-pentyl-4-phenyl-imidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-09-27 | 公開日 | 2016-10-05 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of human TLR8 in complex with MB-343 To Be Published
|
|
5AWD
| Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2015-09-23 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58, 2015
|
|
5AWA
| Crystal structure of human TLR8 in complex with MB-568 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2015-07-03 | 公開日 | 2016-07-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published
|
|
7VAF
| |
7VAG
| |
7VAD
| |