5AWB

Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine)

Summary for 5AWB

Entry DOI	10.2210/pdb5awb/pdb
Related	5AWA 5AWC 5AWD
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	immune system, tlr8, adjuvant, vaccine adjuvants, linnate immunity, glycosylation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	95618.08
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2015-07-03, release date: 2015-09-23, Last modification date: 2020-07-29)
Primary citation	Beesu, M.,Caruso, G.,Salyer, A.C.,Khetani, K.K.,Sil, D.,Weerasinghe, M.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J.Med.Chem., 58:7833-7849, 2015 Cited by PubMed: 26351878 DOI: 10.1021/acs.jmedchem.5b01087 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation