5AWA
Crystal structure of human TLR8 in complex with MB-568
Summary for 5AWA
Entry DOI | 10.2210/pdb5awa/pdb |
Related | 5AWB 5AWC 5AWD |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | immune system, tlr8, adjuvant, vaccine adjuvants, linnate immunity, glycosylation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 96417.85 |
Authors | Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2015-07-03, release date: 2016-07-20, Last modification date: 2020-07-29) |
Primary citation | Beesu, M.,Caruso, G.,Salyer, A.C.D.,Khetani, K.K.,Sil, D.,Weerasinghe, M.,Tanji, H.,Ohto, U.,Shimizu, T.,David, S.A. Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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